氨溴特罗口服液联合胸腔体外振荡排痰仪及异丙托溴铵雾化吸入治疗小儿肺炎的临床效果  

Clinical Effect of Ambroxol Hydrochloride and Clenbuterol Hydrochloride Oral Solution Combinedwith Chest Wall Oscillation Instrument and Ipratropium Bromide Aerosol Inhalationin the Treatment of Pneumonia in Children

作　　者：黄红梅 谢家洪 郭金秀 HUANG Hongmei;XIE Jiahong;GUO Jinxiu(Pediatrics Department of Xin feng County People's Hospital,Xinfeng 341600,Jiangxi,China)

机构地区：[1]信丰县人民医院儿科,江西信丰341600

出　　处：《医学信息》2024年第19期130-133,共4页Journal of Medical Information

基　　金：赣州市指导性科技计划项目(编号:20222ZDX7943)。

摘　　要：目的 研究氨溴特罗口服液联合胸腔体外振荡排痰仪及异丙托溴铵雾化吸入治疗小儿肺炎的临床效果。方法 选取2022年7月-2023年6月信丰县人民医院儿科收治的60例小儿肺炎患者,经随机数字表法分为对照组(30例)与治疗组(30例),对照组给予氨溴特罗口服液与胸腔体外振荡排痰仪治疗,治疗组在其基础上联合异丙托溴铵雾化吸入治疗。比较两组痰液排出时间、肺部湿罗音消失时间、呼吸困难缓解情况(呼吸频率、三凹征比例)、肺部通气情况[血氧饱和度(SaO_(2))、血氧分压(PaO_(2))、血二氧化碳分压(PaCO_(2))]、并发症情况(肺实变、肺不张、低氧血症)、呼吸机使用率及住院时间。结果 治疗组痰液排出时间、肺部湿罗音消失时间短于对照组(P<0.05);两组治疗后呼吸频率、三凹征比例均小于治疗前,且治疗组呼吸频率、三凹征比例小于对照组(P<0.05);两组治疗后SaO_(2)、PaO_(2)高于治疗前,PaCO_(2)低于治疗前,且治疗组SaO_(2)、PaO_(2)高于对照组,PaCO_(2)低于对照组(P<0.05);治疗组肺实变、肺不张、低氧血症发生率小于对照组(P<0.05);治疗组呼吸机使用率小于对照组,住院时间短于对照组(P<0.05)。结论 氨溴特罗、胸腔体外振荡排痰仪与异丙托溴铵雾化吸入治疗小儿肺炎效果确切,可加速痰液排出,缩短患儿肺部湿罗音消失时间,有利于患儿呼吸困难症状的缓解,可改善其肺通气功能,降低肺实变、肺不张、低氧血症的发生风险,减少呼吸机使用率,缩短住院时间。Objective To study the clinical effect of ambroxol hydrochloride and clenbuterol hydrochloride oral solution combined with chest wall oscillation instrument and ipratropium bromide atomization inhalation in the treatment of children with pneumonia.Methods From July 2022 to June 2023,60 children with pneumonia admitted to the Department of Pediatrics,Xinfeng County People's Hospital were selected and divided into control group(30 children)and treatment group(30 children)by random number table method.The control group was treated with ambroxol oral liquid and in vitro oscillation sputum elimination instrument,and the treatment group was treated with ipratropium bromide aerosol inhalation on the basis of the control group.The sputum discharge time,disappearance time of lung moist rales,remission of dyspnea(respiratory rate,proportion of three concave signs),pulmonary ventilation[blood oxygen saturation(SaO_(2)),blood oxygen partial pressure(PaO_(2)),blood carbon dioxide partial pressure(PaCO_(2))],complications(pulmonary consolidation,atelectasis,hypoxemia),ventilator utilization rate and hospitalization time were compared between the two groups.Results The sputum discharge time and lung moist rale disappearance time in the treatment group were shorter than those in the control group(P<0.05).After treatment,the respiratory rate and the proportion of three-concave sign in the two groups were lower than those before treatment,and the respiratory rate and the proportion of three-concave sign in the treatment group were lower than those in the control group(P<0.05).After treatment,SaO_(2) and PaO_(2) in the two groups were higher than those before treatment,PaCO_(2) was lower than that before treatment,and SaO_(2) and PaO_(2) in the treatment group were higher than those in the control group,PaCO_(2) was lower than that in the control group(P<0.05).The incidence of pulmonary consolidation,atelectasis and hypoxemia in the treatment group was lower than that in the control group(P<0.05).The ventilator utilization rate in

关 键 词：小儿肺炎 氨溴特罗 胸腔体外振荡排痰仪 异丙托溴铵 呼吸频率 三凹征 

分 类 号：R725.6[医药卫生—儿科]