脑脊液β2-m、LDH、SAA及铁蛋白水平变化对小儿病毒性脑膜炎感染预后的价值  

Value of Changes of Cerebrospinal Fluid β2-m, LDH, SAA and Ferritin Levels in the Prognosis of Children with Viral Meningitis Infection

作　　者：周祥 禹红[1] ZHOU Xiang;YU Hong(Department of Laboratory,Wuhan Hospital of Traditional Chinese Medicine,Wuhan 430050,Hubei,China)

机构地区：[1]武汉市中医医院检验科,湖北武汉430050

出　　处：《医学信息》2024年第19期156-158,162,共4页Journal of Medical Information

基　　金：武汉市医学科研项目(编号:WZ21C51)。

摘　　要：目的 探讨脑脊液β2-微球蛋白(β2-m)、乳酸脱氢酶(LDH)、淀粉样蛋白A(SAA)及铁蛋白水平变化与小儿病毒性脑膜炎感染预后的关系。方法 选取2022年1月-2023年1月收治于我院的100例病毒性脑膜炎患儿为研究对象,根据患儿疾病预后状况划为预后良好组(52例)和预后不良组(48例);另选取同期于我院收治的排除颅内感染偏头痛患儿50例作为对照组,检测所有患儿脑脊液β2-m、LDH、SAA及铁蛋白水平。结果 预后良好组和预后不良组脑脊液β2-m、LDH、SAA及铁蛋白水平均高于对照组(P<0.05),且预后不良组脑脊液β2-m、LDH、SAA及铁蛋白水平高于预后良好组(P<0.05)。ROC曲线分析显示,脑脊液β2-m、LDH、SAA及铁蛋白单独预测病毒性脑膜炎患儿预后不良的ROC曲线下面积均低于四项指标联合预测的ROC曲线下面积(P<0.05)。结论 β2-m、LDH、SAA及铁蛋白在病毒性脑膜炎患儿的脑脊液中呈较高水平,并与患儿感染严重程度和预后有关,四项指标联合检测对于临床上预测病毒性脑膜炎患儿预后具有较高的应用价值。Objective To investigate the relationship between the changes of cerebrospinal fluidβ2-microglobulin(β2-m),lactate dehydrogenase(LDH),serum amyloid A(SAA)and ferritin levels and the prognosis of viral meningitis infection in children.Methods A total of 100 children with viral meningitis admitted to our hospital from January 2022 to January 2023 were selected as the research objects.According to the prognosis of the disease,they were divided into good prognosis group(52 children)and poor prognosis group(48 children).In addition,50 children with migraine excluding intracranial infection admitted to our hospital during the same period were selected as the control group.The levels ofβ2-m,LDH,SAA and ferritin in cerebrospinal fluid of all children were detected.Results The levels of cerebrospinal fluidβ2-m,LDH,SAA and ferritin in the good prognosis group and the poor prognosis group were higher than those in the control group(P<0.05),and the levels of cerebrospinal fluidβ2-m,LDH,SAA and ferritin in the poor prognosis group were higher than those in the good prognosis group(P<0.05).ROC curve analysis showed that the area under the ROC curve of cerebrospinal fluidβ2-m,LDH,SAA and ferritin alone in predicting the poor prognosis of children with viral meningitis was lower than that of the combined prediction of the four indicators(P<0.05).Conclusion The levels ofβ2-m,LDH,SAA and ferritin in cerebrospinal fluid of children with viral meningitis are high,which are related to the severity of infection and prognosis.The combined detection of the four indicators has high application value in predicting the prognosis of children with viral meningitis.

关 键 词：病毒性脑膜炎 脑脊液 β2-微球蛋白 铁蛋白 乳酸脱氢酶 淀粉样蛋白A 

分 类 号：R446[医药卫生—诊断学]