人颈动脉粥样硬化斑块组织研究的实验设计现状  

Current status of experimental design for studies on human carotid atherosclerotic plaques tissue

作　　者：赵宁 赵文心 吴志远 杨洋 刁永鹏[1] 李拥军[1] Zhao Ning;Zhao Wenxin;Wu Zhiyuan;Yang Yang;Diao Yongpeng;Li Yongjun(Department of Vascular Surgery,Beijing Hospital,National Center of Gerontology,Institute of Geriatric Medicine,Chinese Academy of Medical Sciences,Beijing 100730,China)

机构地区：[1]北京医院血管外科国家老年医学中心,中国医学科学院老年医学研究院,北京100730

出　　处：《中华血管外科杂志》2024年第3期203-208,共6页Chinese Journal of Vascular Surgery

基　　金：北京协和医学院学科建设项目(201920102101);中央保健科研课题(W2017BJ11);中央高水平医院临床科研业务费资助(BJ-2021-205)。

摘　　要：动脉粥样硬化疾病是大部分发达国家和部分发展中国家心脑血管事件发病和死亡的主要原因, 几十年来学者们通过选取不同的标本进行体内和体外实验, 研究其危险因素、发生机制、临床表现和治疗方法。人颈动脉粥样硬化斑块标本在其发病机制和靶向药物研究中具有重要的作用, 不能被动物标本或体外细胞实验完全替代, 常被用于不同的对照实验。这些方法主要以患者症状、斑块特点、不同位置及其他因素为依据。本文主要对上述实验设计方法进行综述并分析了各种研究的优缺点。Atherosclerosis is a major cause of morbidity and mortality from cardiovascular events in most developed and developing countries.Researchers have been investigating its risk factors,mechanisms,clinical manifestations,and therapeutic approaches for decades by using different specimens for in vivo and in vitro experiments.Human carotid atherosclerotic plaque specimens play a significant role in pathogenesis and targeted therapeutic research that cannot be completely replaced by animal specimens or in vitro cell experiments,and they are often used in various control experiments.These experiments are based on patient symptoms,plaque characteristics,locations,and other factors.This article mainly focuses on reviewing the design of experiments and analyzing the advantages and disadvantages of various studies.

关 键 词：人颈动脉斑块 实验设计 动脉粥样硬化 

分 类 号：R543.4[医药卫生—心血管疾病]