小动物PET/MRI的定量性能探索  

Exploring the Quantitative Performance of Small Animal PET/MRI

作　　者：赵富宽[1] 徐栋[1] 唐婕[1] 张波[1] 李伟 王立振[1] 俞惠新[1] 潘栋辉[1] ZHAO Fukuan;XU Dong;TANG Jie;ZHANG Bo;LI Wei;WANG Lizhen;YU Huixin;PAN Donghui(NHC Key Laboratory of Nuclear Medicine,Jiangsu Key Laboratory of Molecular Nuclear Medicine,Jiangsu Institute of Nuclear Medicine,Wuxi 214063,China)

机构地区：[1]国家卫生健康委员会核医学重点实验室,江苏省分子核医学重点实验室,江苏省原子医学研究所,江苏无锡214063

出　　处：《同位素》2024年第5期431-437,共7页Journal of Isotopes

基　　金：国家自然基金面上项目(32371434);BK20192005江苏省基础研究计划(前沿引领技术)。

摘　　要：小动物PET/MRI是结合了PET高性能分子显像功能与MRI卓越软组织对比功能的一体化显像设备,在药物的开发与评价、药理及疾病的机制研究等方面具有独特的优势和应用价值。为了验证该设备在定量分析中的可行性和准确性,本研究探索了Bruker BioSpec 94/30 USR+PET insert对^(18)F的线性检测范围、稳定性及定量性能,同时利用高分辨率MRI图像,去除胆囊、血管等测量干扰项,评估其在动物体内定量的准确性。结果显示,Bruker BioSpec 94/30 USR+PET insert小动物PET/MRI在1~1500μCi的活度范围内具有极佳的线性关系(R^(2)=0.9992),且重复性良好,同时还具有准确的体内定量性能。本研究为后续利用Bruker BioSpec 94/30 USR+PET insert开展核素示踪剂在活体内的显像、分布、代谢及药效评价等研究提供了可靠的数据支持。Small animal PET/MRI is an integrated imaging device that combines the highperformance molecular imaging function of PET with the excellent soft tissue contrast function of MRI,offering unique advantages and significant application value in drug development and evaluation,pharmacology,and mechanistic studies of diseases.To verify the feasibility and accuracy of this device in quantitative analysis,this study evaluated the linear detection range,stability,and quantitative performance of the Bruker BioSpec 94/30 USR + PET insert for ^(18)F.High-resolution MRI images were utilized to remove interference from factors such as the gallbladder and blood vessels,ensuring accurate in vivo quantification in animals.The results demonstrate that the Bruker BioSpec 94/30 USR + PET insert small animal PET/MRI system exhibits excellent linearity(R^(2)=0.999 2) within the activity range of 1-1 500 μCi,good reproducibility,and accurate in vivo quantitative performance.This provides reliable data for subsequent studies utilizing the Bruker BioSpec 94/30 USR + PET insert for in vivo visualization,distribution,metabolism,and pharmacodynamic evaluation of nuclear tracers.

关 键 词：小动物PET/MRI Bruker 定量 标准曲线 稳定性 

分 类 号：TL814[核科学技术—核技术及应用] TL99