氘及其标记化合物在生物医药研究中的应用进展  

Progress in the Application of Deuterium and its Labeled Compounds in Biomedical Research

作　　者：唐金格 任巍[2] 蒋晴晴 于宁 TANG Jinge;REN Wei;JIANG Qingqing;YU Ning(North Sichuan Medical College,Sichuang Nanchong 637000,China;Senior Department of Otolaryngology-head&Neck Surgery,the Sixth Medical Center of PLA General Hospital,Beijing 100853,China)

机构地区：[1]川北医学院,四川南充637000 [2]解放军总医院第六医学中心耳鼻咽喉头颈外科医学部,北京100853

出　　处：《生物技术进展》2024年第5期785-792,共8页Current Biotechnology

基　　金：国家重点研发项目(2020YFC2004001);北京市自然科学基金项目(7222185)。

摘　　要：稳定同位素因具有无放射性、稳定性好等特点,在医药、食品安全、生态环境等领域应用广泛。氘作为氢元素的一种稳定同位素,氘元素标记法具有简单、快捷、价格低等优点。研究发现,氘同位素标记在机体代谢机制、疾病预防及治疗靶点、药理学等生命科学领域具有巨大的应用潜力。综述从氘标记化合物的合成方法、检测技术、氘及其化合物在生物医药研究中的应用等方面进行总结,并对未来发展进行了展望,以期为相关领域的研究与应用提供参考。Stable isotopes are widely used in fields such as medicine,food safety,and ecological environment due to their characteristics of no radioactivity and good stability.Deuterium is a stable isotope of hydrogen element,and deuterium labeling method has the advantages of simplicity,speed,and low cost.Researches have shown that deuterium isotope labeling has enormous potential for application in the field of life sciences such as metabolic mechanisms,disease prevention and treatment targets,pharmacology,etc.The review summarized the synthesis methods,detection techniques,and applications of deuterium and its compounds in biomedical research,and prospected for the future development,in order to provide reference for researchers and applications in related fields.

关 键 词：氘 同位素 生物医药 临床研究 

分 类 号：Q819[生物学—生物工程] R318[医药卫生—生物医学工程]