白细胞介素-22在心血管疾病中的作用  

Roles of Interleukin-22 in Cardiovascular Disease

作　　者：肖玲玲 包明威[1,2,3] XIAO Lingling;BAO Mingwei(Department of Cardiology,Renmin Hospital of Wuhan University,Wuhan 430060,China;Cardiovascular Research Institute of Wuhan University,Wuhan 430060,China;Hubei Key Laboratory of Cardiology,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院心血管内科,武汉430060 [2]武汉大学心血管病研究所,武汉430060 [3]心血管病湖北省重点实验室,武汉430060

出　　处：《生物技术进展》2024年第5期820-824,共5页Current Biotechnology

基　　金：国家自然科学基金项目(81970438)。

摘　　要：白细胞介素22(interleukin-22,IL-22)属于IL-10家族,主要由T辅助细胞Th1、Th17、Th22、天然淋巴细胞(innate lymphoid cells,ILCs)、CD4+T和CD8+T细胞等多种淋巴细胞产生,是具有特异性作用的细胞效应因子。随着研究的深入,IL-22与多种代谢性疾病和心血管疾病的关系逐步得到揭示,IL-22信号在其中可能具有双重作用。就IL-22的来源、功能、调节以及IL-22信号在心血管疾病中的作用等方面的研究进展作出综述,以期对未来心血管疾病的临床治疗提供方案。Interleukin-22(IL-22)belongs to the IL-10 family and is mainly produced by T helper cells Th1,Th17,Th22,innate lymphoid cells(ILCs),CD4+T and CD8+T cells and other lymphocytes.They are cellular effectors with specific effects.With the progress of research,the correlation of IL-22 with a variety of metabolic diseases and cardiovascular diseases has been gradually revealed,and IL-22 signaling may have a dual role in them.This article reviewed the source,function,regulation of IL-22 and the role of IL-22 signaling in cardiovascular diseases,in order to provide a plan for the clinical treatment of cardiovascular diseases in the future.

关 键 词：白细胞介素-22 心血管疾病 代谢 

分 类 号：R714.252[医药卫生—妇产科学] Q731[医药卫生—临床医学]