诱导膜技术治疗下肢骨缺损的研究进展  

Research progress of induced membrane technique in the treatment of lower limb bone defect

作　　者：徐皓月 杨明辉 黄飞[2] 罗刚 XU Hao-yue;YANG Ming-hui;HUANG Fei;LUO Gang(Department of Orthopedics,the Second Hospital Affiliated to Army Medical University,Chongqing 400037,China;Department of Orthopedics,the Second People's Hospital of Neijiang,Neijiang Sichuan 641000,China)

机构地区：[1]陆军军医大学第二附属医院骨科,重庆400037 [2]内江市第二人民医院骨科,四川内江641000

出　　处：《局解手术学杂志》2024年第10期922-926,共5页Journal of Regional Anatomy and Operative Surgery

摘　　要：骨缺损是指骨感染、骨肿瘤、先天性疾病或严重创伤导致的骨结构缺失。由于高能量损伤发生率增加和自身解剖结构特点,下肢骨缺损尤其常见,成为创伤骨科领域的研究难点。传统的治疗方案主要包括带血管蒂的腓骨移植技术、开放植骨技术和骨搬运技术等,但这些技术都存在固有的不足。近年来,诱导膜技术因其操作步骤标准化、简单高效而逐渐用于重建节段性骨缺损。诱导膜技术分为两个阶段:第一阶段是生成具有生物效应的诱导膜,第二阶段是将骨填充物(自体骨、异体骨、人工骨或生物活性物质等)填充到缺损区域,填充后,使用特定的固定方法将骨填充物固定在原有的骨骼结构中。本文对诱导膜技术的基础研究以及国内外治疗下肢骨缺损的相关研究进展进行了综述,旨在讨论其潜在的基础和临床发展方向。Bone defect refers to the loss of bone structure caused by bone infections,bone tumors,congenital diseases,or severe trauma.Due to the increased incidence of high-energy injuries and the characteristics of anatomical structure,lower limb bone defects are particularly common and become the research difficulties in the field of traumatic orthopedics.Traditional treatment options include vascularized fibular grafting,open bone grafting,and bone transport technique,but these techniques have inherent limitations.In recent years,induced membrane technique has gradually been used for the reconstruction of segmental bone defects due to its standardized,simple and efficient operation procedures.Induced membrane technique consists two stages:the first stage is to generate an induced membrane with biological effects,the second stage is to fill the defect area with bone fillers(autologous bone,allogeneic bone,artificial bone or bioactive substances,etc.),then the filled bone graft material is fixed to the existing bone structure by specific fixation methods.In this paper,the basic research of induced membrane technique and the related research progress in the treatment of lower limb bone defect at home and abroad are reviewed,aiming to discuss its potential development direction for basis and clinic.

关 键 词：诱导膜 下肢骨缺损 骨移植 研究进展 

分 类 号：R687.3[医药卫生—骨科学]