神经源性下尿路功能障碍中尿源性生物标志物的研究进展  

Research progress of urogenic biomarkers in neurogenic lower urinary tract dysfunction

作　　者：孙朋浩 宋伟 Sun Penghao;Song Wei(Department of Urology,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan,Shandong 250000,China;Department of Urology,Shandong Provincial Hospital,Shandong University,Jinan,Shandong 250000,China)

机构地区：[1]山东第一医科大学附属省立医院泌尿外科,山东济南250000 [2]山东大学,山东省立医院泌尿外科,山东济南250000

出　　处：《泌尿外科杂志（电子版）》2024年第1期54-58,共5页Journal of Urology for Clinicians(Electronic Version)

基　　金：山东省自然科学基金(ZR2021MH283)。

摘　　要：神经源性下尿路功能障碍(neurogenic lower urinary tract dysfunction,NLUTD)是一类由神经系统病变导致膀胱和(或)尿道功能障碍产生的一系列并发症的疾病总称。目前,对于该疾病的诊断与监测主要基于侵入性尿流动力学检查。有研究发现,一些尿源性生物标志物在NLUTD患者的尿液中升高,例如神经生长因子、前列腺素、炎性细胞因子、中性粒细胞明胶酶相关脂质运载蛋白、参与细胞外基质降解的蛋白质等。这些尿源性生物标志物作为一种非侵入性的监测方法或许可以为该疾病的诊断与监测带来突破,并进一步成为尿动力学检查的一种微创替代方法。基于此,本文总结了多种用于NLUTD及其并发症诊断与监测的尿液生物标志物,并分析目前的研究进展。Neurogenic lower urinary tract dysfunction(NLUTD)is a general term for a series of complications resulting from bladder and/or urethral dysfunction caused by neurological disorders.Currently,diagnosis and monitoring of the disease is based on urodynamics.Several urogenic biomarkers were found to be elevated in the urine of patients with NLUTD,such as nerve growth factors,prostaglandins,inflammatory cytokines,neutrophil gelatinase-associated lipocalin,and proteins involved in extracellular matrix degradation.As a non-invasive monitoring method,these urogenic biomarkers may provide a breakthrough in the diagnosis and monitoring of the disease,and further become a minimally invasive alternative to urodynamic examination.Therefore,this review summarizes a variety of urine biomarkers for the diagnosis and monitoring of NLUTD and its complications,and analyzes the current research progress.

关 键 词：神经源性下尿路功能障碍 神经源性膀胱 尿液分析 生物标志物 

分 类 号：R694.5[医药卫生—泌尿科学]