聚噻吩衍生物/银纳米线结合分子印迹法检测葡萄糖  

Polythiophene Derivatives/Silver Nanowires Combined with Molecular Imprinting for Glucose Sensing

作　　者：刘洋[1] 李丽娟 陈志冉 白婷芳 乌兰格日乐[1] 海文峰 LIU Yang;LI Lijuan;CHEN Zhiran;BAI Tingfang;Wulangerile;HAI Wenfeng(College of Chemistry and Materials,Inner Mongolia Minzu University,Tongliao 028043,China)

机构地区：[1]内蒙古民族大学化学与材料学院,内蒙古通辽028043

出　　处：《内蒙古民族大学学报（自然科学版）》2024年第5期27-33,共7页Journal of Inner Mongolia Minzu University：Natural Sciences Edition

基　　金：国家自然科学基金项目(22164016);内蒙古自治区青年科技英才支持计划项目(NJYT23034);内蒙古自治区自然科学基金项目(2024LHMS02019);内蒙古自治区科技计划项目(2022YFSH0040);内蒙古自治区高等学校科学技术重点研究项目(NJZZ21029)。

摘　　要：通过在银纳米线上沉积3氟苯硼酸接枝的3,4-乙烯二氧噻吩(EDOT-FPBA)和葡萄糖,制备了一种基于表面分子印迹(MIP)法的葡萄糖生物传感器。在玻碳电极(GCE)表面依次沉积银纳米线(AgNWs)、EDOT-FPBA和葡萄糖,然后洗脱葡萄糖模板后得到分子印迹葡萄糖生物传感器。采用电化学阻抗法检测葡萄糖,在0.05~20.00 mmol/L范围内,葡萄糖浓度与电荷转移电阻呈线性关系,检测限低至0.03 mmol/L(R2=0.9905)。此外,该传感器具有良好的特异性、稳定性、可重复使用性和存储稳定性,并且可在生理pH下对葡萄糖进行灵敏检测。A glucose biosensor was fabricated based on surface molecular imprinting(MIP)by depositing 3,4-ethylenedioxythiophene grafted with 3-fluorophenylboronic acid(EDOT-FPBA)and glucose onto silver nanowires.Specifically,silver nanowires(AgNWs),EDOT-FPBA,and glucose were sequentially deposited on the surface of a glassy carbon electrode(GCE).After eluting the glucose template,a molecularly imprinted glucose biosensor was obtained.Using electrochemical impedance spectroscopy,glucose detection was performed,revealing a linear relationship between glucose concentration and charge transfer resistance within the range of 0.05 to 20.00 mmol/L,with a detection limit as low as 0.03 mmol/L(R2=0.9905).Furthermore,the sensor exhibited excellent specificity,stability,reusability,and storage stability,allowing for sensitive detection of glucose at physiological pH levels.

关 键 词：分子印迹法 葡萄糖检测 电化学 生物传感器 银纳米线 

分 类 号：O626[理学—有机化学]