中医药调控miRNA在炎症性肠病中的研究进展  

Research Progress on the Regulation of miRNA by Traditional Chinese Medicine in Inflammatory Bowel Disease

作　　者：徐薇 路晓培 赵敏[2] 丁康[1] 谭妍妍[1] XU Wei;LU Xiaopei;ZHAO Min;DING Kang;TAN Yanyan(Nanjing Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine,Nanjing 210022,China;Nanjing University of Chinese Medicine,Nanjing 210023,China)

机构地区：[1]南京中医药大学附属南京中医院,江苏南京210022 [2]南京中医药大学,江苏南京210023

出　　处：《中医药信息》2024年第10期77-83,共7页Information on Traditional Chinese Medicine

基　　金：江苏省基础研究计划自然科学基金项目(BK20221178);江苏省中医肛肠疾病临床医学创新中心重点项目(GCCXZX-2021);宿迁市科技计划项目(自然科学基金)(K202144);江苏省研究生实践创新计划(SJCX23_0950)。

摘　　要：炎症性肠病(IBD)是一种慢性反复发作肠道炎症性疾病,发病机制尚不明确,目前普遍认为与遗传易感性、肠道菌群、免疫紊乱和环境等多个因素相关。多项研究表明微小核糖核酸(miRNA)是IBD发生、发展的关键调节因子,有望成为IBD的诊断标志物和治疗靶标。中医药防治IBD历史悠久,不仅疗效显著,还具有多分子、多靶点、多通路协同调控作用等优势。本文综述多种相关miRNA在IBD中的作用机制及中医药干预miRNA防治炎症性肠病的研究成果,发现中医药可通过干预多种miRNA表达,参与调控肠上皮细胞受损、炎症、细胞自噬、血管新生等病理损伤过程,从而发挥修复肠上皮功能障碍和重建免疫稳态、延缓病情的作用。Inflammatory bowel disease(IBD)is a chronic recurrent inflammatory condition of the gastrointestinal tract with an unclear pathogenesis.It is widely believed to be associated with multiple factors,including genetic susceptibility,gut microbiota,immune dysregulation,and environmental influences.Numerous studies have indicated that microRNAs(miRNAs)are key regulatory factors in the occurrence and development of IBD and have the potential to serve as diagnostic biomarkers and therapeutic targets.Traditional Chinese Medicine(TCM)has a long history of preventing and treating IBD,offering significant efficacy along with advantages such as multi-molecule,multi-target,and multi-pathway synergistic regulation.This article reviews the mechanisms of various miRNAs in IBD and the research findings on TCM intervention in miRNA regulation for IBD treatment.It is found that TCM can modulate the expression of various miRNAs,thereby participating in the regulation of pathological processes such as intestinal epithelial cell damage,inflammation,autophagy,and angiogenesis.This modulation helps to repair intestinal epithelial dysfunction,reestablish immune homeostasis,and slow disease progression.

关 键 词：炎症性肠病 微小核糖核酸 炎症反应 肠道屏障 细胞自噬 血管新生 

分 类 号：R259[医药卫生—中西医结合]