砂半理中汤联合四联疗法治疗老年慢性萎缩性胃炎伴Hp感染临床观察  

Efficacy observation of Shaban Lizhong decoction and quadruple therapy on elderly chronic atrophic gastritis with Hp infection

作　　者：王铃清 代景娜[1] 付利然[1] WANG Ling-qing;DAI Jing-na;FU Li-ran(Zhengzhou People's Hospital,Henan Province,Zhengzhou450003,China)

机构地区：[1]河南省郑州人民医院,郑州450003

出　　处：《山西中医》2024年第10期14-16,共3页Shanxi Journal of Traditional Chinese Medicine

基　　金：河南省科技攻关计划项目(编号:LHgJ20220776)。

摘　　要：目的:观察砂半理中汤联合四联疗法治疗老年慢性萎缩性胃炎伴Hp感染的治疗效果。方法:选取86例老年慢性萎缩性胃炎伴Hp感染患者随机分为两组各43例。对照组予四联疗法治疗,治疗组在对照组基础上予砂半理中汤治疗,疗程为4周。比较两组临床疗效、Hp根除率、中医症状评分、胃黏膜病灶组织情况、血清胃泌素-17(G-17)、胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)。结果:治疗组总有效率为93.02%,明显高于对照组的76.74%(P﹤0.05);治疗组Hp根除率为83.72%,明显高于对照组的62.79%(P﹤0.05)。治疗后,治疗组中医症状积分低于对照组(P﹤0.05);治疗组各胃镜黏膜征象积分明显低于对照组(P﹤0.05),血清G-17、PGⅠ水平均明显高于对照组(P﹤0.05)。结论:砂半理中汤联合四联疗法治疗老年慢性萎缩性胃炎伴Hp感染可提高治疗效果和Hp根除率,改善胃镜下胃黏膜征象,促进胃黏膜修复。Objective:To observe the clinical efficacy of Shaban Lizhong decoction and quadruple therapy on elderly chronic atrophic gastritis with Hp infection.Methods:86 cases of patients with elderly chronic atrophic gastritis with Hp infection were selected and randomly divided into two groups,43 cases in each group.The control group was treated with quadruple therapy,while the treatment group was treated plus with Shaban Lizhong decoction on the basis of control group.Both groups were treated for 4 weeks.Clinical efficacy,Hp eradication rate,TCM symptom score,tissue condition of gastric mucosal lesion,serum gastrin-17(G-17),pepsinogen I(PG I),pepsinogen II(PG II)were compared between two groups.Results:The total effective rate of treatment group was 93.02%,which was significantly higher than 76.74%of control group(P﹤0.05).Hp eradication rate of treatment group was 83.72%,which was significantly higher than 62.79%of control group(P﹤0.05).After treatment,TCM symptom score of treatment group was lower than that of control group(P﹤0.05);the score of each gastroscope sign of gastric mucosa in treatment group was significantly lower than that in control group(P﹤0.05);the levels of serum G-17 and PG I of treatment group were significantly higher than those of control group(P﹤0.05).Conclusion:Shaban Lizhong decoction and quadruple therapy for treating elderly chronic atrophic gastritis with Hp infection can enhance the therapeutic effect and Hp eradication rate,improve the gastroscope signs of gastric mucosa,and promote the repair of gastric mucosa.

关 键 词：老年 慢性萎缩性胃炎 HP感染 砂半理中汤 中西医结合疗法 

分 类 号：R259[医药卫生—中西医结合]