NLR、D-二聚体、RLP-C水平与青年急性心肌梗死发生及病变严重程度的相关性  

The correlation between NLR,D-dimer,RLP-C levels and the occurrence and severity of acute myocardial infarction in young patients

作　　者：麦麦吐逊·麦麦提 依力夏提·艾尼瓦尔 艾合麦提江·凯赛尔 Maimaituxun Maimaiti;Yilixiati Ainiwaer;Aihemaitijiang Kaisaier(Department of Clinical Laboratory,the First People′s Hospital of Kashgar,Kashgar 844000,China)

机构地区：[1]喀什地区第一人民医院检验科,喀什844000

出　　处：《中国医师杂志》2024年第9期1364-1368,共5页Journal of Chinese Physician

摘　　要：目的探究中性粒细胞与淋巴细胞比值(NLR)、D-二聚体、剩余脂蛋白胆固醇(RLP-C)水平与青年急性心肌梗死发生及病变严重程度的相关性。方法回顾性选取2020年6月至2022年6月在喀什地区第一人民医院就诊的96例青年急性心肌梗死患者纳入观察组,另选取同期100例在本院进行体检的青年健康志愿者纳入对照组,比较两组受试者的血清NLR、D-二聚体、RLP-C水平,对患者行冠状动脉造影检查,根据Gensini评分将观察组患者分为轻度狭窄、中度狭窄、重度狭窄亚组,比较不同亚组间患者的血清NLR、D-二聚体、RLP-C水平,采用Pearson相关分析法评估血清NLR、D-二聚体、RLP-C水平与患者Gensini评分的相关性。采用受试者工作特征(ROC)曲线探究NLR、D-二聚体、RLP-C水平对青年急性心肌梗死发生和冠状动脉重度狭窄的诊断价值。结果观察组患者NLR、D-二聚体、RLP-C水平明显高于对照组(均P<0.05)。ROC曲线分析结果显示,NLR、D-二聚体、RLP-C诊断青年急性心肌梗死发生的曲线下面积(AUC)分别为0.942、0.865、0.970(均P<0.05)。重度狭窄组患者的NLR、D-二聚体、RLP-C水平均高于轻中度狭窄组(均P<0.05)。Pearson相关分析显示青年急性心肌梗死患者的NLR、D-二聚体、RLP-C水平与Gensini评分呈正相关(r=0.806、0.843、0.851,均P<0.001)。ROC曲线分析结果显示,NLR、D-二聚体、RLP-C水平诊断青年急性心肌梗死患者冠状动脉重度狭窄的AUC分别为0.915、0.874、0.922(均P<0.05)。结论青年急性心肌梗死患者NLR、D-二聚体、RLP-C水平升高,且与患者的病变严重程度呈正相关,临床应予以密切关注。Objective To investigate the correlation between neutrophil to lymphocyte ratio(NLR),D-dimer,residual lipoprotein cholesterol(RLP-C)levels and the occurrence and severity of acute myocardial infarction in young adults.Methods A total of 96 young patients with acute myocardial infarction who visited the First People′s Hospital of Kashgar from June 2020 to June 2022 were retrospectively selected as the observation group,and 100 healthy volunteers who underwent physical examinations at our hospital during the same period were selected as the control group.The serum NLR,D-dimer,and RLP-C levels of the two groups of patients were compared.Coronary angiography was performed on the patients,and the observation group patients were divided into mild stenosis,moderate stenosis,and severe stenosis subgroups based on their Gensini scores.The serum NLR,D-dimer,and RLP-C levels of patients in different subgroups were recorded and compared.Pearson correlation analysis was used to determine the correlation between serum NLR,D-dimer,and RLP-C levels and patients′Gensini scores.The diagnostic value of NLR,D-dimer,and RLP-C levels in young patients with acute myocardial infarction and severe coronary artery stenosis was explored using receiver operating characteristic(ROC)curves.Results The levels of NLR,D-dimer,and RLP-C in the observation group were significantly higher than those in the control group(all P<0.05).The ROC curve analysis results showed that the area under the curve(AUC)for diagnosing acute myocardial infarction in young patients with NLR,D-dimer,and RLP-C were 0.942,0.865,and 0.970,respectively(all P<0.05).The levels of NLR,D-dimer,and RLP-C in patients with severe stenosis were higher than those in patients with mild to moderate stenosis(all P<0.05).Pearson correlation analysis showed that the levels of NLR,D-dimer,RLP-C in young patients with acute myocardial infarction were positively correlated with Gensini score(r=0.806,0.843,0.851,all P<0.001).The ROC curve analysis results showed that the AUC values of N

关 键 词：心肌梗死 中性粒细胞 淋巴细胞 D-二聚体 剩余脂蛋白胆固醇 

分 类 号：R542.22[医药卫生—心血管疾病]