单倍体造血干细胞移植后Wernicke脑病3例报告并文献复习  

Wernicke's encephalopathy after haploid hematopoietic stem cell transplantation:3 cases report and literature review

作　　者：肖倩倩 于晓林 宋晓晨 李文君 邓磊 侯怡西 周芳 Xiao Qianqian;Yu Xiaolin;Song Xiaochen;Li Wenjun;Deng Lei;Hou Yixi;Zhou Fang(School of Clinical Medicine,Shandong Second Medical University,Weifang 261053,China;Department of Hematology,The 960th Hospital of The People's Liberation Army(PLA)Joint Logistics Support Force,Jinan 250031,China)

机构地区：[1]山东第二医科大学临床医学院,潍坊261053 [2]解放军联勤保障部队第九六〇医院血液病科,济南250031

出　　处：《中华血液学杂志》2024年第8期781-784,共4页Chinese Journal of Hematology

摘　　要：例1,女,27岁,ALK阳性间变性大细胞淋巴瘤/白血病(ALCL);例2,男,27岁,急性髓系白血病;例3,男,56岁,骨髓增生异常综合征。3例患者单倍体造血干细胞移植后长期伴有重度口腔黏膜炎、恶心、呕吐、腹泻等症状,导致进食明显受限,分别于移植后50、38、50 d出现神经、精神症状,经头颅磁共振成像检查诊断为Wernicke脑病,经维生素B_(1)静脉滴注治疗后病情明显好转。Case 1:A 27-year-old female with ALK-positive anaplastic large cell lymphoma/leukemia;Case 2:A 27-year-old male with acute myeloid leukemia;Case 3:A 56-year-old male with myelodysplastic syndrome.These three patients underwent haploid hematopoietic stem cell transplantation and experienced severe oral mucosal inflammation,nausea,vomiting,diarrhea,and other symptoms over a long period,which significantly restricted eating.Neurological and psychiatric symptoms appeared at 50,38,and 50 days following transplantation,respectively.The diagnosis of Wernicke encephalopathy was made by head magnetic resonance imaging,whereas the condition improved significantly after intravenous infusion of vitamin B_(1).

关 键 词：WERNICKE脑病 骨髓增生异常综合征 急性髓系白血病 间变性大细胞淋巴瘤 单倍体造血干细胞移植 精神症状 维生素B 

分 类 号：R457.7[医药卫生—治疗学] R742[医药卫生—临床医学] R733