The Role of Progenitor Cells in the Pathogenesis of Arteriosclerosis  

作　　者：Yuesheng Zhang Ziyin Guan Hui Gong Zhichao Ni Qingzhong Xiao Xiaogang Guo Qingbo Xu 

机构地区：[1]Department of Cardiology,the First Affiliated Hospital,Zhejiang UniversitySchool of Medicine,Hangzhou,Zhejiang 310000,China [2]Centre for ClinicalPharmacology and Precision Medicine,William Harvey Research Institute,Facultyof Medicine and Dentistry,Queen Mary University of London,London,UnitedKingdom

出　　处：《Cardiology Discovery》2024年第3期231-244,共14页心血管病探索（英文）

基　　金：supported by grants from the National Natural Science Foundation of China(82030008,82170489,and U21A20337).

摘　　要：The increasing incidence of arteriosclerosis has become a significant global health burden.Arteriosclerosis is characterized by the thickening and hardening of arterial walls,which can lead to the narrowing or complete blockage of blood vessels.However,the pathogenesis of the disease remains incompletely understood.Recent research has shown that stem and progenitor cells found in the bone marrow and local vessel walls play a role in the development of arteriosclerosis by differentiating into various types of vascular cells,including endothelial cells,smooth muscle cells,fibroblasts,and inflammatory cells.This review aims to provide a comprehensive understanding of the role of stem and progenitor cells in the pathogenesis of arteriosclerosis,shedding light on the underlying mechanisms and potential therapeutic approaches for this disease.

关 键 词：Stem cells Vascular progenitors Endothelial repair Neointimal formation ARTERIOSCLEROSIS 

分 类 号：R543.5[医药卫生—心血管疾病]