甲型肝炎病毒和戊型肝炎病毒免疫球蛋白抗体与肝功能指标表达水平  

Expression Levels of Immunoglobulin Antibodies and Liver Function Indicators in Hepatitis A and HEV Viruses

作　　者：陈炎玲 CHEN Yanling(Department of Laboratory,Fuqing City Center for Disease Control and Prevention,Fuzhou 350300,China)

机构地区：[1]福清市疾病预防控制中心检验科,福州350300

出　　处：《中国医药指南》2024年第29期48-50,共3页Guide of China Medicine

摘　　要：目的探究甲型肝炎病毒(HAV)和戊型肝炎病毒(HEV)、免疫球蛋白M(IgM)抗体与肝功能指标的相关性。方法收集甲型病毒性肝炎、戊型病毒性肝炎患者为研究对象,测定纳入者HAV-IgM抗体、HEV-IgM抗体和肝功能指标。依据患者病毒-IgM抗体检测结果,将其分为抗体阴性组和阳性组。比较两组肝功能指标表达水平。结果与病毒-IgM抗体阴性组比,抗体阳性组血清AST、ALT、AST/ALT、DBIL、TBIL、TBA水平升高(P<0.05),且病毒-IgM抗体强阳性表达者血清AST、ALT、AST/ALT、DBIL、TBIL、TBA水平高于病毒-IgM抗体中度强度表达者和病毒-IgM抗体弱度表达者,病毒-IgM抗体中度表达者血清水平高于病毒-IgM抗体弱度表达者(P<0.05)。结论HAV-IgM抗体和HEV-IgM抗体阳性,甲型病毒性肝炎和戊型病毒性肝炎患者更易出现肝功能损伤,且病毒-IgM抗体表达强度越高,肝损伤越严重。Objective To explore the correlation between hepatitis A virus(HAV)and hepatitis V virus(HEV),immunoglobulin M(IgM)antibodies and liver function index.Methods Patients with viral hepatitis A and viral hepatitis Ewere collected to determine HAV-IgM antibody,HEV-IgM antibody and liver function index.According to the results of patient virus-IgM antibody test,they were divided into antibody negative and positive groups.The expression levels of liver function indicators were compared between the two groups.Results Compared with the virus-IgM antibody negative group,serum AST,ALT,AST/ALT,DBIL,TBIL,and TBA levels were higher(P<0.05),and serum AST,ALT,AST/ALT,TBIL of virus-IgM antibody and virus-IgM antibody and weak levels of virus-IgM antibody were significantly higher than that of virus-IgM antibody(P<0.05).Conclusions Patients with positive HAV-IgM antibody and HEV-IgM antibody were more likely to have liver function impairment,and the higher the expression intensity of virus-igm antibody,the more serious the liver injury.

关 键 词：甲型病毒性肝炎 戊型病毒性肝炎 病毒 免疫球蛋白M 肝功能 

分 类 号：R512.6[医药卫生—内科学]