基层医疗机构中不同种类抗生素治疗多重耐药鲍曼不动杆菌肺部老年感染的临床应用及安全性评估  

Clinical Application and Safety Evaluation of Different Kinds of Antibiotics in Treatment of Multidrug-Resistant Acinetobacter Baumannii Lung Infection in Elderly Patients in Primary Medical Institutions

作　　者：卢华 LU Hua(Pharmacy Department,Jiangkou Hospital of Hanjiang District,Putian City,Putian 351115,China)

机构地区：[1]莆田市涵江区江口镇卫生院药剂科,莆田351115

出　　处：《中国医药指南》2024年第29期122-125,共4页Guide of China Medicine

摘　　要：目的探讨基层医疗机构中不同种类抗生素治疗多重耐药鲍曼不动杆菌肺部老年感染的临床应用及安全性评估。方法选取2022年12月至2023年12月涵江区江口镇卫生院收治的100例多重耐药鲍曼不动杆菌肺部老年感染患者为研究对象,根据抗生素类型不同分为头孢曲松组、头孢唑啉钠组、左氧氟沙星组及阿奇霉素组,各组25例。记录治疗期间用药情况并判断不同抗生素的临床应用价值。结果头孢曲松组、头孢唑啉钠组、左氧氟沙星组以及阿奇霉素组临床疗效分别为88.00%、84.00%、88.00%、92.00%,组间对比后,四组患者临床治疗有效率占比无统计学意义(P>0.05);治疗后,左氧氟沙星组治疗总费用较其他三组低,头孢唑啉钠组较头孢曲松组、阿奇霉素组低,头孢曲松组较阿奇霉素组低(P<0.05);对比四组患者治疗后TNF-α、CRP、IL-6、IL-8变化,差异无统计学意义(P>0.05);四组不同种类抗生素药物不良反应比较无统计差异(P>0.05)。结论多重耐药鲍曼不动杆菌肺部老年感染患者治疗过程中不同抗生素治疗疗效、炎症因子及不良反应情况无明显差别,但对比用药经济学方面,左氧氟沙星治疗费用较低,临床上应根据患者情况科学性选择合适的抗生素治疗。Objective To investigate the clinical application and safety evaluation of different kinds of antibiotics in the treatment of multi-drug resistant Acinetobacter baumannii lung infection in elderly patients in primary medical institutions.Methods A total of 100 patients with pneumonia treated in Jiangkou Town Health Center of Hanjiang District from December 2022 to December 2023 were selected as the study objects.According to different types of antibiotics,they were divided into ceftriaxone group,cefazolin sodium group,levofloxacin group and azithromycin group,25 cases in each group.The drug use during treatment was recorded and the clinical application value of different antibiotics was evaluated.Results The clinical efficacy of ceftriaxone group,cefazolin sodium group,levofloxacin group and azithromycin group were 88.00%,84.00%,88.00%and 92.00%,respectively.After comparison between groups,there was no statistical significance in the proportion of clinical effective rate of the four groups(P>0.05).After treatment,the total cost of levofloxacin group was lower than that of the other three groups,that of cefazolin sodium group was lower than that of ceftriaxone group and azithromycin group,and that of ceftriaxone group was lower than that of azithromycin group(P<0.05).The changes of TNF-α,CRP,IL-6 and IL-8 in four groups after treatment were not statistically significant(P>0.05).There was no statistical difference in the adverse reactions of different kinds of antibiotics among the four groups(P>0.05).Conclusions There is no significant difference in the efficacy,inflammatory factors,and adverse reactions of different antibiotics in the treatment of elderly patients with multidrug-resistant acinetobacter baumannii pulmonary infection.However,compared with the economic aspects of medication,levofloxacin has a lower treatment cost.In clinical practice,appropriate antibiotic treatment should be scientifically selected based on the patient's condition.

关 键 词：基层医疗 抗生素 呼吸系统感染 安全性 治疗费用 

分 类 号：R563[医药卫生—呼吸系统] R978.1[医药卫生—内科学]