营养支持与重组人生长激素联合治疗对特发性矮小症患儿生长指标的影响分析  

Analysis of the Effect of Nutritional Support Combined with Recombinant Human Growth Hormone on the Growth Index of Children with Idiopathic Short Stature

作　　者：余涛 YU Tao(Department of Pediatrics,Xinyang Xixian People's Hospital,Xixian 464300,Henan,China)

机构地区：[1]河南省信阳市息县人民医院儿科,河南息县464300

出　　处：《系统医学》2024年第16期16-19,共4页Systems Medicine

摘　　要：目的 分析特发性矮小症治疗过程中营养支持与重组人生长激素联合治疗对于患儿生长指标的影响。方法 回顾性选取2020年2月—2023年2月河南省信阳市息县人民医院儿科100例特发性矮小症患儿的临床资料,依据治疗方法不同分为两组,每组50例,营养支持与重组人生长激素联合治疗的患儿为联合治疗组,重组人生长激素单独治疗的患儿为单独治疗组。比较两组生长发育指标、骨代谢指标、并发症发生情况。结果 治疗后,联合治疗组患儿的体质量、身高、身高标准差、骨龄、生长速率均高于单独治疗组,差异有统计学意义(P均<0.05);治疗后,联合治疗组的饥饿激素、空腹血糖水平分别为(4.13±0.56)ng/mL、(4.06±0.57)mmol/L,均低于单独治疗组(4.97±0.53)ng/mL、(4.45±0.50)mmol/L,差异有统计学意义(t=7.704、3.637,P均<0.001);骨钙素、骨源性骨碱性磷酸酶、I型前胶原氨基端前肽、胰岛素样生长因子-1、胰岛素样生长因子结合蛋白-3水平均高于单独治疗组,差异有统计学意义(P均<0.05);总甲状腺素低于单独治疗组,差异有统计学意义(P<0.05);两组患儿的并发症发生率比较,差异无统计学意义(P>0.05)。结论 特发性矮小症治疗中营养支持与重组人生长激素联合治疗较重组人生长激素单独治疗更能对患儿生长指标进行改善。Objective To analyze the effect of nutritional support combined with recombinant human growth hormone on the growth index of children with idiopathic short stature during treatment.Methods The clinical data of one hundred children with idiopathic short stature in Department of Pediatrics,Xixian People's Hospital of Xinyang City,Henan Province from February 2020 to February 2023 were retrospectively selected and divided into two groups according to different treatment methods,with fifty cases in each group.The children treated with nutritional support combined with recombinant human growth hormone were in the combined treatment group,and the children treated with recombinant human growth hormone alone were in the single treatment group.The growth and development indexes,bone metabolism indexes and complications were compared between the two groups.Results After treatment,the body weight,height,height standard deviation,bone age and growth rate of the children in the combined treatment group were higher than those in the single treatment group,and the differences were statistically significant(all P<0.05).After treatment,the levels of hunger hormone and fasting blood glucose in the combined treatment group were(4.13±0.56) ng/mL and(4.06±0.57) mmol/L,respectively,which were lower than those in the single treatment group(4.97±0.53) ng/mL and(4.45±0.50) mmol/L,the differences were statistically significant(t=7.704,3.637,both P<0.05).The levels of osteocalcin,bone alkaline phosphatase,type I procollagen amino terminal propeptide,insulin-like growth factor-1 and insulin-like growth factor binding protein-3 were higher than those in the single treatment group,the differences were statistically significant(all P<0.05).The total thyroxine was lower than that in the single treatment group,and the difference was statistically significant(P<0.05).There was no statistically ignificant difference in the incidence of complications between the two groups(P>0.05).Conclusion The combination of nutritional support and recombinan

关 键 词：特发性矮小症 营养支持 重组人生长激素 生长发育指标 并发症 

分 类 号：R72[医药卫生—儿科]