标准剂量与半剂量替罗非班辅助PCI治疗急性ST段抬高型心肌梗死效果对比  

Comparison of the Effect of Standard Dose and Half Dose Tirofiban as an Adjuvant PCI Treatment for Acute ST-segment Elevation Myocardial Infarction

作　　者：单丽丽 苏国英 SHAN Lili;SU Guoying(Department of Cardiology,Shanghe County People's Hospital,Jinan City,Jinan 251600,Shandong,China;Department of Cardiology,Affiliated Central Hospital of Shandong First Medical University,Jinan 250013,Shandong,China)

机构地区：[1]济南市商河县人民医院心内科,山东济南251600 [2]山东第一医科大学附属中心医院心内科,山东济南250013

出　　处：《系统医学》2024年第16期75-78,共4页Systems Medicine

摘　　要：目的 对比标准剂量与半剂量替罗非班辅助经皮冠状动脉介入(percutaneous coronary intervention,PCI)治疗对急性ST段抬高型心肌梗死的效果。方法 非随机选取2022年1月—2023年6月济南市商河县人民医院收治的94例急性ST段抬高型心肌梗死患者为研究对象。按治疗方法分为标准剂量组与半剂量组,每组47例患者,两组分别以标准剂量与半剂量替罗非班进行辅助PCI治疗。对比两组心肌再灌注指标、心功能指标、并发症。结果 两组患者心肌再灌注指标比较,差异无统计学意义(P均>0.05)。半剂量组心功能指标水平优于标准剂量组,差异有统计学意义(P均<0.05)。半剂量组并发症发生率为4.26%(2/47),高于标准剂量组的19.15%(9/47),差异有统计学意义(χ^(2)=5.045,P<0.05)。结论 在PCI治疗中应用替罗非班能有效缓解急性ST段抬高型心肌梗死患者心肌再灌注情况,半剂量替罗非班改善患者心功能的效果更优,能有效降低出血不良反应的发生风险。Objective To compare the efficacy of standard dose and half-dose tirofiban assisted percutaneous coronary intervention(PCI) on acute ST-segment elevation myocardial infarction.Methods Ninety-four patients with acute ST-segment elevation myocardial infarction admitted to Shanghe County People's Hospital in Jinan City from January 2022 to June 2023 were non-randomly selected as study subjects.According to the treatment method,they were divided into standard-dose group and half-dose group,with fotry-seven patients in each group,and the two groups were treated with standard-measurement and half-dose tirofiban for adjuvant PCI,respectively.Compared the myocardial reperfusion indexes,cardiac function indexes,and complications of the two groups.Results There were no statistically significant differences in myocardial reperfusion indexes between the two groups(all P>0.05).The levels of cardiac function indexes in the half-dose group were better than those in the standard-dose group,and the differences were statistically significant(all P<0.05).The complication rate of the half-dose group was 4.26%(2/47),which was higher than 19.15%(9/47) in the standard-dose group,and the difference was statistically significant(χ^(2)=5.045,P<0.05).Conclusion The application of tirofiban in PCI therapy can effectively alleviate myocardial reperfusion in patients with acute ST-segment elevation myocardial infarction,and half-dose tirofiban improves patients' cardiac function more effectively and effectively reduces the risk of bleeding adverse effects.

关 键 词：替罗非班 经皮冠状动脉介入 急性ST段抬高 心肌损伤 心肌梗死 

分 类 号：R542.2[医药卫生—心血管疾病]