右美托咪定对腹腔镜腹股沟疝修补术患者血流动力学及麻醉复苏效果的影响  

Effect of dexmedetomidine on hemodynamics and anesthesia resuscitation in patients undergoing laparoscopic inguinal hernia repair

作　　者：李先锋 何懿 程贞永 邓国魁 胡波 谢红 王莉 王小燕 李晓明 Li Xianfeng;He Yi;Cheng Zhenyong;Deng Guokui;Hu Bo;Xie Hong;Wang Li;Wang Xiaoyan;Li Xiaoming(Department of Anesthesiology and Perioperative Medicine,Hefei Cancer Hospital,Chinese Academy of Sciences,Hefei 230031,Anhui Province,China;Department of Anesthesiology,Affiliated Hospital of West Anhui Health Vocational College,Lu'an,237005,Anhui Province,China Corresponding author:Li Xiao)

机构地区：[1]中国科学院合肥肿瘤医院麻醉与围术期医学科,230031 [2]皖西卫生职业学院附属医院麻醉科,安徽六安237005

出　　处：《中华疝和腹壁外科杂志（电子版）》2024年第4期437-441,共5页Chinese Journal of Hernia and Abdominal Wall Surgery(Electronic Edition)

基　　金：安徽高校自然科学研究项目(KJ2021A1368)。

摘　　要：目的探讨右美托咪定对腹腔镜腹股沟疝修补术患者血流动力学及麻醉复苏效果的影响。方法纳入2019年2月至2023年9月于中国科学院合肥肿瘤医院接受腹腔镜腹股沟疝修补术的106例患者,采用随机数字表法分为右美托咪定组(n=53)和传统麻醉组(n=53)。比较2组患者在手术过程中的心率、血压、呼吸功能、麻醉苏醒指标、麻醉药物用量及患者满意度。结果气腹15 min时,右美托咪定组患者的心率、血压均较传统麻醉组更低[心率(65.4±8.1)次/min比(72.3±9.4)次/min,收缩压(95.4±11.3)mmHg比(103.2±12.5)mmHg、舒张压(61.7±7.6)mmHg比(68.4±8.3)mmHg、平均动脉压(77.1±9.2)mmHg比(84.6±10.1)mmHg],差异均有统计学意义(P<0.05)。2组患者的呼吸功能均在正常范围内,且差异无统计学意义(P>0.05)。右美托咪定组麻醉苏醒相关指标均较传统麻醉组降低[术后苏醒时间[(10.3±2.6)min比(13.1±2.8)min、苏醒躁动发生率(3.8%比18.7%)、自主呼吸恢复时间(7.3±1.7)min比(8.2±1.9)min、术后拔管时间(12.6±2.4)min比(15.3±2.7)min、麻醉苏醒时VAS评分(2.2±0.5)分比(2.7±0.9)分],差异均有统计学意义(P<0.05)。右美托咪定组的麻醉药物使用量较传统麻醉组减少,分别为(360.3±35.9)μg和(426.7±40.6)μg;右美托咪定组患者满意度较传统麻醉组高,分别为(92.4±5.1)分和(84.7±6.2)分,差异有统计学意义(P<0.05)。结论与传统麻醉方法相比,右美托咪定用于腹腔镜腹股沟疝修补术中可使患者血流动力学更加稳定,且具有一定的麻醉复苏优势。Objective To explore the effects of dexmedetomidine on the hemodynamics and anesthesia resuscitation of patients receiving laparoscopic inguinal hernia repair.Methods A total of 106 patients who underwent laparoscopic inguinal hernia repair in Hefei Cancer Hospital,Chinese Academy of Sciences from February 2019 to September 2023 were enrolled.They were divided into dexmedetomidine group(n=53)and traditional anesthesia group(n=53)by random number table method.The heart rate,blood pressure,respiratory function,anesthesia recovery index,anesthetic dosage and patient satisfaction were compared between the two groups.Results At 15 min of pneumoperitoneum,the heart rate and blood pressure in the dexmedetomidine group were lower than those in the traditional anesthesia group[heart rate(65.4±8.1)times/min vs.(72.3±9.4)times/min,systolic blood pressure(95.4±11.3)mmHg vs.(103.2±12.5)mmHg,diastolic blood pressure[(61.7±7.6)mmHg vs.(68.4±8.3)mmHg,mean arterial pressure(77.1±9.2)mmHg vs.(84.6±10.1)mmHg],the differences were statistically significant(P<0.05).The respiratory function of the two groups was within the normal range,and there was no statistically significant difference between the two groups(P>0.05).The related indexes of anesthesia recovery in dexmedetomidine group were lower than those in traditional anesthesia group[postoperative recovery time(10.3±2.6)min vs.(13.1±2.8)min,incidence of emergence agitation(3.8%vs.18.7%),spontaneous breathing recovery time(7.3±1.7)min vs.(8.2±1.9)min,postoperative extubation time(12.6±2.4)min vs.(15.3±2.7)min,VAS score at anesthesia recovery(2.2±0.5)points vs.(2.7±0.9)points],the differences were statistically significant(P<0.05).The dosage of anesthetic in the dexmedetomidine group was lower than that in the traditional anesthesia group,which were(360.3±35.9)μg and(426.7±40.6)μg,respectively.The satisfaction of patients in the dexmedetomidine group was higher,(92.4±5.1)points,and the traditional anesthesia group was(84.7±6.2)points,the difference was statist

关 键 词：右美托咪定 麻醉 腹腔镜 疝 腹股沟 疝修补术 血流动力学 麻醉复苏 

分 类 号：R614[医药卫生—麻醉学]