2型糖尿病患者血清VASH-1、TIMP-1水平与视网膜病变的关系  

Relationship between serum VASH-1,TIMP-1 levels and retinopathy in patients with type 2 diabetes mellitus

作　　者：苏争宏 姜旭光 SU Zhenghong;JIANG Xuguang(Department of Fundus Diseases,Shangluo Eye Hospital,Shangluo,Shaanxi 726000,China;Department of Fundus Diseases,Aier Eye Hospital,Xi′an,Shaanxi 710068,China)

机构地区：[1]陕西省商洛眼科医院眼底病科,陕西商洛726000 [2]陕西省西安爱尔古城眼科医院眼底病科,陕西西安710068

出　　处：《检验医学与临床》2024年第20期3013-3016,共4页Laboratory Medicine and Clinic

基　　金：陕西省重点研发项目(2022SF-367)。

摘　　要：目的探讨2型糖尿病(T2DM)患者血清血管生成抑制蛋白-1(VASH-1)、金属蛋白酶组织抑制物1(TIMP-1)与糖尿病视网膜病变的关系。方法选取2020年1月至2021年1月陕西省商洛眼科医院收治的79例T2DM患者作为研究对象。根据眼底荧光血管造影结果将患者分为无视网膜病变组、视网膜病变组。另选取40例同期健康体检者作为对照组。采用酶联免疫吸附试验检测血清VASH-1、TIMP-1水平。绘制受试者工作特征(ROC)曲线评估血清VASH-1、TIMP-1水平对T2DM患者发生视网膜病变的预测价值。采用多因素Logistic回归分析T2DM患者发生视网膜病变的危险因素。结果无视网膜病变组纳入45例患者、视网膜病变组纳入34例患者。无视网膜病变组与视网膜病变组FPG、2 h PG、HbA1c、UACR水平均高于对照组,且视网膜病变组均高于无视网膜病变组,差异均有统计学意义(P<0.05)。视网膜病变组T2DM病程长于无视网膜病变组,差异有统计学意义(P<0.05)。无视网膜病变组与视网膜病变组血清VASH-1水平均高于对照组,TIMP-1水平均低于对照组,且视网膜病变组血清VASH-1水平高于无视网膜病变组,视网膜病变组血清TIMP-1水平低于无视网膜病变组,差异均有统计学意义(P<0.05)。ROC曲线分析结果显示,血清VASH-1、TIMP-1预测T2DM患者发生视网膜病变的曲线下面积分别为0.807、0.847。多因素Logistic回归分析结果显示,病程长、血清VASH-1高水平、TIMP-1低水平为T2DM患者发生视网膜病变的危险因素(P<0.05)。结论发生视网膜病变的T2DM患者血清VASH-1水平升高、TIMP-1水平降低。血清VASH-1、TIMP-1为T2DM患者发生视网膜病变的影响因素,二者有望作为临床诊治T2DM患者发生视网膜病变的生物标志物。Objective To investigate the relationship between serum angiogenesis inhibitor protein-1(VASH-1),tissue inhibitor of metalloproteinase-1(TIMP-1)and diabetic retinopathy in patients with type 2 diabetes mellitus(T2DM).Methods A total of 79 patients with T2DM admitted to Shangluo Eye Hospital of Shaanxi Province from January 2020 to January 2021 were selected as the research objects.According to the results of fundus fluorescein angiography,the patients were divided into non-retinopathy group and retinopathy group.Another 40 healthy subjects were selected as the control group.The serum levels of VASH-1 and TIMP-1 were detected by enzyme-linked immunosorbent assay.Receiver operating characteristic(ROC)curve was drawn to evaluate the predictive value of serum VASH-1 and TIMP-1 levels for retinopathy in T2DM patients.Multivariate Logistic regression was used to analyze the risk factors of retinopathy in T2DM patients.Results There were 45 patients in the non-retinopathy group and 34 patients in the retinopathy group.The levels of FPG,2 h PG,HbA1C and UACR in the non-retinopathy group and the retinopathy group were higher than those in the control group,and those in the retinopathy group were higher than those in the non-retinopathy group,and the differences were statistically significant(P<0.05).The duration of T2DM in the retinopathy group was longer than that in the non-retinopathy group,and the difference was statistically significant(P<0.05).The serum levels of VASH-1 in the non-retinopathy group and the retinopathy group were higher than those in the control group,and the serum levels of TIMP-1 in the retinopathy group were lower than those in the control group,and the serum levels of VASH-1 in the retinopathy group were higher than those in the non-retinopathy group,and the serum levels of TIMP-1 in the retinopathy group were lower than those in the non-retinopathy group,and the differences were statistically significant(P<0.05).ROC curve analysis showed that the area under the curve of serum VASH-1 and TIMP-1 f

关 键 词：2型糖尿病 视网膜病变 血管生成抑制蛋白-1 金属蛋白酶组织抑制物1 炎症反应 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]