功能性消化不良患儿血清单核细胞趋化蛋白-1和前列腺素E_(2)水平变化及临床意义  

Changes and clinical significance of serum monocyte chemoattractant protein-1 and prostaglandin E_(2) levels in children with functional dyspepsia

作　　者：李洁 侯志芳 肖二明 张旭 LI Jie;HOU Zhifang;XIAO Erming;ZHANG Xu(the Second Department of Pediatrics,Shijiazhuang Maternal and Child Health Care Hospital of Hebei Province,Shijiazhuang,Hebei,050000;Department of Pediatrics,Renqiu People's Hospital of Hebei Province,Renqiu,Hebei,062550;Department of Neonatology,Langfang Maternal and Child Health Care Hospital of Hebei Province,Langfang,Hebei,065000)

机构地区：[1]河北省石家庄市妇幼保健院儿二科,河北石家庄050000 [2]河北省任丘市人民医院儿科,河北任丘062550 [3]河北省廊坊市妇幼保健院新生儿科,河北廊坊065000

出　　处：《实用临床医药杂志》2024年第17期79-82,87,共5页Journal of Clinical Medicine in Practice

基　　金：河北省中医药管理局2023年度中医药类科学研究课题项目(2023164)。

摘　　要：目的 探讨功能性消化不良(FD)患儿血清单核细胞趋化蛋白-1(MCP-1)、前列腺素E_(2)(PGE_(2))水平变化及临床意义。方法 回顾性纳入2022年10月—2023年10月收治的89例FD患儿作为FD组,另选取同期健康儿童91例作为对照组。根据FD患儿病情严重程度将其分为轻度组36例、中度组33例、重度组20例。采用酶联免疫吸附法(ELISA)检测血清MCP-1、PGE_(2)水平。采用整体症状量表(GOSS)评分对患儿病情进行评估,并检测所有患儿胃排空情况。采用皮尔逊(Pearson)及斯皮尔曼(Spearman)相关性分析探讨血清MCP-1、PGE_(2)水平与胃半排空情况和FD症状评分的相关性。结果 FD组血清MCP-1水平高于对照组,PGE_(2)水平低于对照组,差异有统计学意义(P<0.05)。重度组患儿血清MCP-1水平高于中度组与轻度组,PGE_(2)水平低于中度组与轻度组,中度组血清MCP-1水平高于轻度组,PGE_(2)水平低于轻度组,差异均有统计学意义(P<0.05)。FD组患儿胃半排空时间与餐后2 h残留率均高于对照组,差异有统计学意义(P<0.05)。FD患儿血清MCP-1与胃半排空时间、餐后2 h残留率呈正相关(P<0.05),血清PGE_(2)与胃排空时间、餐后2 h残留率呈负相关(P<0.05)。FD患儿血清MCP-1与上腹烧灼感、早饱感、嗳气、上腹痛及GOSS总分呈正相关(r=0.611、0.509、0.504、0.491、0.513,P<0.05),PGE_(2)与上腹烧灼感、早饱感、嗳气、上腹痛、反酸及GOSS总分呈负相关(r=-0.516、-0.561、-0.493、-0.533、-0.497、-0.482,P<0.05)。结论 FD患儿血清MCP-1升高,PGE_(2)降低,MCP-1、PGE_(2)水平与病情严重程度、胃排空情况、FD部分症状密切相关。Objective To investigate the changes and clinical significance of serum monocyte chemoattractant protein-1(MCP-1) and prostaglandin E_2(PGE_2) levels in children with functional dyspepsia(FD).Methods A retrospective study was conducted to enroll 89 FD children admitted from October 2022 to October 2023 as FD group,and 91 healthy children in the same period were selected as control group.The FD group was further divided into mild group(n=36),moderate group(n=33),and severe group(n=20) based on the severity of the disease.The serum levels of MCP-1and PGE_(2) were detected by enzyme-linked immunosorbent assay(ELISA).The severity of the disease was assessed by the Global Overall Symptom Score(GOSS),and gastric emptying was evaluated in all the children.Pearson and Spearman correlation analyses were performed to explore the correlations of serum MCP-1 and PGE_(2) levels with gastric half-emptying time and FD symptom scores.Results The serum MCP-1 level in the FD group was significantly higher than that in the control group,while the PGE2 level was significantly lower(P <0.05).In the severe group,the serum MCP-1 level was significantly higher while the PGE_(2) level was significantly lower than that in the moderate and mild groups,and similar differences were significantly observed between the moderate and mild groups(P <0.05).The gastric half-emptying time and postprandial 2-hour residual rate were significantly higher in the FD group than the control group(P <0.05).Serum MCP-1 in FD children was positively correlated with gastric half-emptying time and postprandial 2-hour residual rate(P <0.05),while serum PGE_(2) was negatively correlated with these parameters(P <0.05).Serum MCP-1 in FD children was significantly positively correlated with upper abdominal burning sensation,early satiety,belching,upper abdominal pain,and the total GOSS score(r=0.611,0.509,0.504,0.491,0.513;P <0.05),while PGE2 was significantly negatively correlated with upper abdominal burning sensation,early satiety,belching,upper abdominal pain,aci

关 键 词：功能性消化不良 单核细胞趋化蛋白-1 前列腺素E_(2) 整体症状量表 

分 类 号：R725.1[医药卫生—儿科] R571[医药卫生—临床医学] R446.11