尿肝脏型脂肪酸结合蛋白、血清半乳糖凝集素3与痛风患者早期肾功能损伤的相关性研究  

Relationships of urinary liver-type fatty acid-binding protein and serum galectin-3 with early renal dysfunction in gout patients

作　　者：朱咏梅 杜琳 王丹 ZHU Yongmei;DU Lin;WANG Dan(Department of Nephrology,Chang'an Hospital of Shaanxi Province,Xi'an,Shaanxi,710016)

机构地区：[1]陕西省长安医院肾内科,陕西西安710016

出　　处：《实用临床医药杂志》2024年第18期76-80,共5页Journal of Clinical Medicine in Practice

基　　金：陕西省科技计划项目(2022D045)。

摘　　要：目的 探讨尿肝脏型脂肪酸结合蛋白(L-FABP)、血清半乳糖凝集素-3(Gal-3)与痛风患者早期肾功能损伤的关系。方法 选取2022年1月—2023年12月本院收治的痛风患者124例为痛风组,根据尿白蛋白与肌酐比值(UACR)分为无肾损伤组42例和早期肾损伤组82例;另选取同期在本院体检的健康志愿者40例作为对照组。检测所有受试者的尿素氮、肌酐、胱抑素C、尿L-FABP、血清Gal-3水平。采用受试者操作特征(ROC)曲线分析尿L-FABP、血清Gal-3对痛风患者早期肾功能损伤的评估价值。结果 痛风组胱抑素C、尿L-FABP、血清Gal-3水平高于对照组,差异有统计学意义(P<0.05)。早期肾损伤组胱抑素C、尿L-FABP、血清Gal-3水平高于无肾损伤组,差异有统计学意义(P<0.05)。Pearson分析显示,痛风患者尿L-FABP水平与UACR、胱抑素C、血清Gal-3均呈正相关(P<0.05),痛风患者血清Gal-3水平与UACR、胱抑素C、尿L-FABP均呈正相关(P<0.05)。ROC曲线显示,尿L-FABP、血清Gal-3对痛风患者早期肾功能损伤的评估价值较高,曲线下面积分别为0.804(95%CI:0.726~0.882)、0.781(95%CI:0.697~0.866),二者联合的曲线下面积为0.923(95%CI:0.874~0.972)。结论 痛风患者尿L-FABP、血清Gal-3均异常升高,其表达水平与患者早期肾功能损伤密切相关。尿L-FABP联合血清Gal-3评估痛风患者早期肾功能损伤的价值较高。Objective To investigate the relationships of urinary liver-type fatty acid-binding protein(L-FABP) and serum galectin-3(Gal-3) with early renal dysfunction in gout patients.Methods A total of 124 gout patients in the hospital from January 2022 to December 2023 were selected as gout group,and they were divided into non-renal injury group with 42 cases and early renal injury group with 82 cases according to the urinary albumin-to-creatinine ratio(UACR).Additionally,40 healthy volunteers with physical examinations in the hospital in the same period were selected as control group.The levels of urea nitrogen,creatinine,cystatin C,urinary L-FABP,and serum Gal-3 were measured in all participants.Receiver operating characteristic(ROC) curve was used to analyze the diagnostic value of urinary L-FABP and serum Gal-3 for early renal dysfunction in gout patients.Results The levels of cystatin C,urinary L-FABP,and serum Gal-3 in the gout group were significantly higher than those in the control group(P<0.05).The levels of cystatin C,urinary L-FABP,and serum Gal-3 in the early renal injury group were significantly higher than those in the non-renal injury group(P<0.05).Pearson analysis showed that urinary L-FABP level in gout patients was significantly positively correlated with UACR,cystatin C,and serum Gal-3(P<0.05),and serum Gal-3 level in gout patients was significantly positively correlated with UACR,cystatin C,and urinary L-FABP(P<0.05).ROC curve analysis indicated that urinary L-FABP and serum Gal-3 had high diagnostic values for assessing early renal dysfunction in gout patients,with areas under the curve(AUCs) of 0.804(95% CI,0.726 to 0.882) and 0.781(95% CI,0.697 to 0.866) respectively.The AUC for the combination of urinary L-FABP and serum Gal-3 was 0.923(95% CI,0.874 to 0.972).Conclusion The levels of urinary L-FABP and serum Gal-3 are abnormally elevated in gout patients,and their expression levels are closely related to early renal dysfunction.The combination of urinary L-FABP and serum Gal-3 has a high diagnost

关 键 词：痛风 肾功能 肝脏型脂肪酸结合蛋白 半乳糖凝集素-3 

分 类 号：R692[医药卫生—泌尿科学] R319[医药卫生—外科学] R971[医药卫生—临床医学]