“Yin-Yang philosophy”for the design of anticancer drug delivery nanoparticles  

作　　者：Yanwen Ai Yuan Tian Jiaming Qiao Changnan Wang Huafei Li 

机构地区：[1]School of Lifesciences,Shanghai University,Shanghai,China

出　　处：《Biomaterials Translational》2024年第2期144-156,共13页生物材料转化电子杂志（英文）

基　　金：supported by the Natural Science Foundation of Shanghai(No.21ZR1422800);“One Belt One Road”International Cooperation Project of Shanghai Municipal Committee of Science and Technology(No.19410740900).

摘　　要：Understanding the in vivo transport process provides guidelines for designing ideal nanoparticles(NPs)with higher efficacy and fewer off-target effects.Many factors,such as particle size,morphology,surface potential,structural stability,and etc.,may influence the delivering process of NPs due to the existence of various physiological barriers within the body.Herein,we summarise the distinct influences of NP physicochemical properties on the four consecutive in vivo transport steps:(1)navigating with bloodstream within blood vessels,(2)transport across vasculature walls into tumour tissues,(3)intratumoural transport through the interstitial space,and(4)cellular uptake&intracellular delivery by cancerous cells.We found that the philosophy behind the current consensus for NP design has certain similarities to the“Yin-Yang”theory in traditional Chinese culture.Almost all physicochemical properties,regardless of big or small sizes,long or short length,positive or negative zeta potentials,are double-edged swords.The balance of potential benefits and side effects,drug selectivity and accessibility should be fully considered when optimising particle design,similar to the“Yin-Yang harmony”.This paper presents a comprehensive review of the advancements in NPs research,focusing on their distinct features in tumour targeting,drug delivery,and cell uptake.Additionally,it deliberates on future developmental trends and potential obstacles,thereby aiming to uncover the ways these characteristics influence the NPs’biological activity and provide theoretical guidance for the targeted delivery of NPs.

关 键 词：in vivo drug delivery nanoparticle design on-demand drug release targeting strategy “Yin-Yang harmony” 

分 类 号：TB383[一般工业技术—材料科学与工程]