A non-antibiotic organic coating on ZA6-1 surface releasing different concentrations of sodium dodecyl sulphate/levulinic acid for orthopaedic application  

作　　者：Feng Zou Deren Zhao Yangkai Liu Qiqi Lu Hulin Liu Zilin Chen Yaxing Fang Xiaodong Tan Yunjie Xiang Xue Feng Yongping Zhang Xi Rao 

机构地区：[1]School of Materials and Energy,Southwest University,Chongqing,China [2]Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function Manufacturing,Southwest University,Chongqing,China [3]Department of Clinical Laboratory,University-Town Hospital of Chongqing Medical University,Chongqing,China

出　　处：《Biosurface and Biotribology》2024年第2期42-51,共10页生物表面与生物摩擦学（英文）

基　　金：Grant/Award Number:52271250;Venture and Innovation Support Program for Chongqing Overseas Returnees,Grant/Award Number:cx2021106。

摘　　要：Bone implantation surgery is often accompanied by bacterial infection,resulting in infectious bone non-union,pathological fracture and other serious consequences,which will aggravate the pain of patients.A non-antibiotic coating consisting of sodium dodecyl sulphate(SDS)and levulinic acid(LA)with different concentrations was prepared by the authors on the zinc–aluminium alloy(ZA6-1)using a wet chemistry treatment for orthopaedic application.The influence of SDS/LA concentrations on the surface morphology,composition and performance of the developed coating was investigated.The results showed that as-prepared coating on a zinc alloy surface could improve the substrate's corrosion resistance and increase the degradation rate from 0.82 to 19.70μm/year upon raising the SDS/LA concentration.Furthermore,higher hydrophilicity(<14°),better cell proliferation(>100%)and morphology,as well as good cell adhesion and differentiation(ALP>95%for 7 days)were observed on coated zinc alloys.The increased SDS/LA concentration slightly weakens the biocompatibility and enhances the antibacterial performance of coated zinc alloys due to the synergistic effect of SDS/LA.Overall,the coating comprising 6 wt.%SDS and 9 wt.%LA showed excellent antibacterial action with a high level of biocompatibility,confirming its potential application for orthopaedic implants.

关 键 词：ANTIBACTERIAL BIOCOMPATIBILITY BIOMATERIALS material property 

分 类 号：R318[医药卫生—生物医学工程]