Enhancing the biological functionality of poly(lactic-co-glycolic acid)cage-like structures through surface modification with micro-and nano-sized hydroxyapatite particles  

作　　者：Dongbiao Chang Siyu Li Zhenfan Bai Jing You Lili Cao Qingcao Li Huan Tan Yan Zheng Feilun Ye Jie Weng 

机构地区：[1]College of Medicine(Institute of Biomedical Engineering),Southwest Jiaotong University,Chengdu,China [2]Key Laboratory of Advanced Technologies of Materials Ministry of Education,School of Materials Science and Engineering,Southwest Jiaotong University,Chengdu,China [3]Medical Cosmetology Department,Chengdu Third People's Hospital(Affiliated Hospital of Southwest Jiaotong University),Chengdu,China

出　　处：《Biosurface and Biotribology》2024年第2期63-75,共13页生物表面与生物摩擦学（英文）

基　　金：National Natural Science Foundation of China,Grant/Award Numbers:22172120,52071277。

摘　　要：Biomaterials with exceptional performance are crucial for addressing the challenges of complex bone regeneration.Compared with traditional three-dimensional scaffolds,injectable microspheres enable new strategies for the treatment of irregular bone defects.Biodegradable poly(lactic-co-glycolic acid)has found widespread applications as microcarriers of drugs,proteins,and other active macromolecules.Applied to the surface of poly(lactic-co-glycolic acid)cage-like structures(PLGA-CAS),hydroxyapatite(HA)effectively reduces inflammation while enhancing biological effects.In this study,we loaded the surface of PLGA-CAS with micro-and nano-hydroxyapatite particles,referred to asμHA/PLGA-CAS and nHA/PLGA-CAS,respectively.Subsequently,their material characteristics and biological effects were assessed.The incorporation of hydroxyapatite onto PLGA-CAS resulted in enhanced surface roughness and hydrophilicity,coupled with improved thermal stability and delayed degradation.Furthermore,μHA/PLGACAS induced osteogenic differentiation of osteoblast precursor cells,while nHA/PLGACAS improved endothelial cell adhesion and stimulated angiogenic differentiation in vitro.Collectively,these findings suggest thatμHA/PLGA-CAS and nHA/PLGA-CAS,each with distinct characteristics,hold significant potential for application as microcarriers in various biomedical contexts.

关 键 词：biological functions HYDROXYAPATITE material characteristics surface modification 

分 类 号：R318[医药卫生—生物医学工程]