Advances in magnesium-containing bioceramics for bone repair  

作　　者：Lei Qi Tong Zhao Jinge Yan Weiwen Ge Weidong Jiang Jing Wang Mazaher Gholipourmalekabadi Kaili Lin Xiuhui Wang Lei Zhang 

机构地区：[1]Department of Oral&Cranio-Maxillofacial Surgery,Shanghai Ninth People’s Hospital,College of Stomatology,Shanghai Jiao Tong University School of Medicine,National Clinical Research Center for Oral Diseases,Shanghai Key Laboratory of Stomatology&Shanghai Research Institute of Stomatology,Shanghai,China [2]Institute of Translational Medicine,Shanghai University,Organoid Research Center,Shanghai University,Shanghai,China [3]Department’s Education Deputy,Department of Medical Biotechnology,Iran University of Medical Sciences,Tehran,Iran

出　　处：《Biomaterials Translational》2024年第1期3-20,共18页生物材料转化电子杂志（英文）

基　　金：supported by the National Key R&D Program of China(No.2023YFC2414106);National Natural Science Foundation of China(Nos.32271379,82072396);Science and Technology Commission of Shanghai Municipality(Nos.21140900102,21490711700,21140900103);Disciplinary Characteristic Biobank Project of Ninth People’s Hospital affiliated to Shanghai Jiao Tong University School of Medicine(No.YBKB202110);the Interdisciplinary Program of Shanghai Jiao Tong University(No.YG2021ZD12);Cross disciplinary Research Fund of Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine(No.JYJC202219);Shanghai’s Top Priority Research Center(No.2022ZZ01017);CAMS Innovation Fund for Medical Sciences(No.CIFMS,2019-I2M-5-037).

摘　　要：Reconstruction of bone defects or fractures caused by ageing,trauma and tumour resection is still a great challenge in clinical treatment.Although autologous bone graft is considered as gold standard,the source of natural bone is limited.In recent years,regenerative therapy based on bioactive materials has been proposed for bone reconstruction.Specially,numerous studies have indicated that bioactive ceramics including silicate and phosphate bioceramics exhibit excellent osteoinductivity and osteoconductivity,further promote bone regeneration.In addition,magnesium(Mg)element,as an indispensable mineral element,plays a vital role in promoting bone mineralisation and formation.In this review,different types of Mg-containing bioceramics including Mg-containing calcium phosphate-based bioceramics(such as Mg-hydroxyapatite,Mg-biphasic calcium phosphate),Mg-containing calcium silicate-based bioceramics(such as Mg_(2)SiO_(4),Ca_(2)MgSi_(2)O_(7) and Mg-doped bioglass),Mg-based biocements,Mg-containing metal/polymer-bioceramic composites were systematacially summarised.Additionally,the fabrication technologies and their materiobiological effects were deeply discussed.Clinical applications and perspectives of magnesium-containing bioceramics for bone repair are highlighted.Overall,Mg-containing bioceramics are regarded as regenerative therapy with their optimised performance.Furthermore,more in-depth two-way researches on their performance and structure are essential to satisfy their clinical needs.

关 键 词：bioactive ions BIOCERAMICS bone repair MAGNESIUM OSTEOCONDUCTIVITY 

分 类 号：TQ174.1[化学工程—陶瓷工业] R318[化学工程—硅酸盐工业]