基于数据挖掘研究宋欣伟治疗硬皮病用药规律  

Medication Rules of SONG Xinwei in Treating Scleroderma Based on Data Mining

作　　者：俞夏莉 骆淳 朱于青 陈心茹 宋欣伟[1] YU Xiai;LUO Chun;ZHU Yuqing;CHEN Xinru;SONG Xinwei(The First Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou Zhejiang 310006,China;The First Clinical College of Zhejiang Chinese Medical University,Hangzhou Zhejiang 310053,China)

机构地区：[1]浙江中医药大学附属第一医院,浙江杭州310006 [2]浙江中医药大学第一临床医学院,浙江杭州310053

出　　处：《新中医》2024年第19期7-12,共6页New Chinese Medicine

基　　金：浙江省中医药科技计划项目(2020ZB083,2021ZB099);第七批全国老中医药专家学术经验继承工作项目(国中医药办人教函〔2021〕272号)。

摘　　要：目的:通过数据挖掘的方法分析宋欣伟教授治疗硬皮病的处方用药规律。方法:收集2011年8月—2021年8月于浙江中医药大学第一附属医院宋教授门诊就诊的硬皮病患者资料,构建处方数据库,对药物的累计频数、药物性味等进行描述性分析,并对高频药物进行系统聚类分析、关联规则分析。结果:本研究共纳入处方1764首,涉及药物341味。使用频次居前5位的为黄芪、白术、当归、熟地黄、党参。药味以甘味最多,其次主要为辛味和苦味;药性以温性最多。中药功效分类中,累计频数前6位的类别依次为补虚药、活血化瘀药、清热药、解表药、化痰止咳平喘药、温里药。关联分析得到常用核心药物组合37个。总结出宋教授治疗硬皮病的核心处方为黄芪、党参、山茱萸、山药、川芎、当归、桂枝、熟地黄、玉竹、白术、白芍、红花、附子、鸡血藤、鹿角霜、金银花、连翘、麻黄、黄精。结论:宋教授认为硬皮病由寒痰瘀三邪致病,阳虚寒盛、痰瘀互结为基本病机,以温阳散寒、化痰祛瘀为基本治则,通过药物之间的配伍发挥良好的临床疗效。Objective:To analyze the rules of prescription and medication of Professor SONG Xinwei in the treatment of scleroderma based on data mining.Methods:Data of patients with scleroderma who visited Professor SONG's outpatient clinic at the First Affiliated Hospital of Zhejiang Chinese Medical University from August 2011 to August 2021 were collected to construct a prescription database.Descriptive analysis was conducted on the cumulative frequency,nature,and flavor of Chinese medicinals;systematic clustering analysis and association rule analysis were performed on high-frequency Chinese medicinals.Results:A total of 1764 prescriptions were included into the study,involving 341 medicinals.The top five most frequently used medicinals were Astragali Radix,Atractylodis Macrocephalae Rhizoma,Angelicae Sinensis Radix,Rehmanniae Radix Praeparata,and Codonopsis Radix.The most common medicinal flavor was sweet,followed by acrid and bitter flavors;the main medicinal nature was warm.In the classification of Chinese medicinals efficacy,the top six categories in terms of cumulative frequency were deficiency-supplementing medicinals,medicinals for invigorating blood and dissolving stasis,heat-clearing medicinals,exterior-releasing medicinals,medicinals for resolving phlegm,relieving cough,and calming panting,and the interior-warming medicinals.Association analysis identified 37 commonly used core medicinal combinations.The core prescription for Professor SONG's treatment of scleroderma was summarized as Astragali Radix,Codonopsis Radix,Corni Fructus,Dioscoreae Rhizoma,Chuanxiong Rhizoma,Angelicae Sinensis Radix,Cinnamomi Ramulus,Rehmanniae Radix Praeparata,Polygonati Odorati Rhizoma,Atractylodis Macrocephalae Rhizoma,Paeoniae Radix Alba,Carthami Flos,Aconiti Lateralis Radix Praeparata,Spatholobi Caulis,Cervi Cornu Degelatinatum,Lonicerae Japonicae Flos,Forsythiae Fructus,Ephedrae Herba,and Polygonati Rhizoma.Conclusion:Professor SONG believes that scleroderma is caused by the three pathogenic factors of cold,phlegm,and blood stasi

关 键 词：硬皮病 数据挖掘 用药规律 宋欣伟 阳虚寒盛、痰瘀互结 温阳散寒、化痰祛瘀 

分 类 号：R593.25[医药卫生—内科学]