加味五虎汤联合阿奇霉素序贯疗法治疗儿童肺炎支原体肺炎临床研究  

Clinical Study on Modified Wuhu Decoction Combined with Azithromycin Sequential Therapy for Mycoplasma Pneumoniae Pneumonia in Children

作　　者：王菲菲 奚伟健 王佳佳 WANG Feifei;XI Weijian;WANG Jiajia(Wenzhou Hospital of Integrative Traditional Chinese and Western Medicine,Wenzhou Zhejiang 325000,China)

机构地区：[1]温州市中西医结合医院,浙江温州325000

出　　处：《新中医》2024年第19期44-49,共6页New Chinese Medicine

摘　　要：目的:观察加味五虎汤联合阿奇霉素序贯疗法在痰热闭肺型儿童肺炎支原体肺炎中的效果。方法:将80例痰热闭肺型肺炎支原体肺炎患儿随机分为对照组、观察组各40例。2组均应用阿奇霉素序贯疗法治疗,观察组加予加味五虎汤治疗。2组均治疗2周。治疗前后评定中医证候评分,检测炎症因子[白细胞介素-6(IL-6)、C-反应蛋白(CRP)]、T淋巴细胞亚群指标(CD4^(+)T淋巴细胞、CD8^(+)T淋巴细胞、CD4^(+)/CD8^(+)比值)和免疫球蛋白[免疫球蛋白G(IgG)、免疫球蛋白A(IgA)、免疫球蛋白M(IgM)]。比较2组临床疗效。结果:治疗2周后,观察组总有效率高于对照组(P<0.05)。2组中医证候积分均较治疗前降低(P<0.05)。观察组中医证候积分低于对照组(P<0.05)。2组IL-6、CRP水平均较治疗前降低(P<0.05)。观察组IL-6、CRP水平均低于对照组(P<0.05)。2组CD4^(+)T淋巴细胞水平、CD4^(+)/CD8^(+)比值均较治疗前升高(P<0.05)。观察组CD8^(+)T淋巴细胞水平较治疗前下降(P<0.05)。观察组CD4^(+)T淋巴细胞水平、CD4^(+)/CD8^(+)比值均高于对照组,CD8^(+)T淋巴细胞水平低于对照组,差异均有统计学意义(P<0.05)。观察组IgG、IgA水平均较治疗前升高,IgM水平较治疗前降低,差异均有统计学意义(P<0.05)。观察组IgG、IgA水平均高于对照组,IgM水平低于对照组,差异均有统计学意义(P<0.05)。结论:应用加味五虎汤联合阿奇霉素序贯疗法治疗痰热闭肺型儿童肺炎支原体肺炎临床疗效良好,能促进症状的缓解,减轻机体的炎症反应,提高患儿的免疫力。Objective:This study aimed to evaluate the effectiveness of modified Wuhu Decoction in conjunction with Azithromycin sequential therapy for treating mycoplasma pneumoniae pneumonia in children differentiated as phlegm-heat obstructing the lung type.Methods:A total of 80 children with mycoplasma pneumoniae of phlegm-heat obstruction the lung tpye were selected and randomly divided into the control group or the observation group,with 40 participants in each group.Both groups received Azithromycin sequential therapy,while the observation group also received modified Wuhu Decoction.The treatment lasted for two weeks.The following indexes were compared between the two groups before and after treatment:traditional Chinese medicine(TCM)syndrome score,Pro-inflammatory markers[interleukin-6(IL-6)and C-reactive protein(CRP)],T lymphocyte subpopulation indicators(CD4^(+)T lymphocyte,CD8^(+)T lymphocyte,and the CD4^(+)/CD8^(+)ratio),and immune factors[immunoglobulin G(IgG),immunoglobulin A(IgA),and immunoglobulin M(IgM)].The clinical effects in the two gruops were compared.Results:After two-week treatment,the total effective rate in the observation group was higher than that in the control group(P<0.05).The TCM syndrome score in both groups were lower when compared with those before treatment(P<0.05).The TCM syndrome scores in the observation group was lower than that in the control group(P<0.05).The levels of IL-6 and CRP in both groups were decreased when compared with those before treatment(P<0.05).The levels of IL-6 and CRP in the observation group were lower than those in the control group(P<0.05).The CD4^(+)T lymphocyte levels and CD4^(+)/CD8^(+)ratios in both groups were increased when compared with those before treatment(P<0.05).The CD8^(+)T lymphocyte level in the observation group was decreased when compared with that before treatment(P<0.05).The CD4^(+)T lymphocyte level and CD4^(+)/CD8^(+)ratios in the observation group were higher than those in the control group,while CD8^(+)T lymphocyte level in the observation

关 键 词：肺炎支原体肺炎 儿童 痰热闭肺证 五虎汤 阿奇霉素 炎症反应 T淋巴细胞 

分 类 号：R725.6[医药卫生—儿科]