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作 者:陈湘宜 张里援[1] 陈苗苗[1] 张虹[1] CHEN Xiangyi;ZHANG Liyuan;CHEN Miaomiao;ZHANG Hong(Traditional Chinese Medicine Gynecology Department,Wenzhou Traditional Chinese Medicine Hospital,Wenzhou Zhejiang 325000,China)
出 处:《新中医》2024年第19期97-100,共4页New Chinese Medicine
基 金:温州市科研项目(Y20211082)。
摘 要:目的:观察固本安胎汤联合地屈孕酮片治疗复发性流产(RSA)的临床疗效。方法:选取100例脾肾两虚型RSA患者,按就诊顺序抽签法随机分为2组各50例。对照组给予地屈孕酮片治疗,研究组给予地屈孕酮片联合固本安胎汤治疗。比较2组临床疗效、用药安全性和妊娠结局,并比较2组治疗前后孕激素水平、中医证候评分。结果:研究组总有效率94.00%,高于对照组78.00%(P<0.05)。治疗后,2组中医证候评分均较治疗前降低(P<0.05),且研究组低于对照组(P<0.05)。治疗后,2组血清孕酮、雌二醇、绒毛膜促性腺激素水平均较治疗前升高(P<0.05),且研究组各项指标均高于对照组(P<0.05)。2组用药至妊娠12周,肝肾功能检查和血、尿、便常规检查均无异常。研究组28周妊娠率高于对照组(P<0.05)。结论:固本安胎汤与地屈孕酮片联合可以改善脾肾两虚型RSA患者孕激素水平及妊娠结局,效果较好,用药安全性高。Objective:To observe the clinical effect of Guben Antai Decoction combined with Dydrogesterone Tablets on recurrent spontaneous abortion(RSA).Methods:A total of 100 RSA patients of spleen-kidney deficiency type were selected and divided into the two groups according to the order of treatment by drawing lots,with 50 patients each.The control group was treated with Dydrogesterone Tablets,and the study group was treated with Dydrogesterone Tablets combined with Guben Antai Decoction.Compared the clinical effects,medication safety,and pregnancy outcomes between the two groups,and compared the progesterone levels and traditional Chinese medicine syndrome scores in the two groups before and after treatment.Results:The total effective rate was 94.00%in the study group,which was higher than that of 78.00%in the control group(P<0.05).After treatment,the traditional Chinese medicine syndrome scores in both groups were decreased(P<0.05),and the score in the study group was lower than that in the control group(P<0.05).After treatment,the levels of serum progesterone,estradiol,and chorionic gonadotropin were increased in both groups(P<0.05),and the levels of indicators above in the study group were higher than those in the control group(P<0.05).Both groups were medicated until 12 weeks of pregnancy,and there showed no abnormality in the liver and kidney function tests,as well as routine blood,urine,and stool tests.The 28-week pregnancy rate in the study group was higher than that in the control group(P<0.05).Conclusion:The combination of Guben Antai Decoction and Dydrogesterone Tablets can improve the progesterone levels and pregnancy outcomes in RSA patients of spleen-kidney deficiency type,with good efficacy and high medication safety.
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