中西医结合治疗湿热蕴结型中重度寻常型痤疮临床研究  

Clinical Study on Integrated Chinese and Western Medicine for Moderate to Severe Acne Vulgaris of Damp-Heat Accumulation Type

作　　者：胡学军 何艳 HU Xuejun;HE Yan(Department of Dermatology,Jiashan Hospital of Traditional Chinese Medicine,Jiashan Zhejiang 314100,China;Department of Chinese Internal Medicine,Jiashan Hospital of Traditional Chinese Medicine,Jiashan Zhejiang 314100,China)

机构地区：[1]嘉善县中医院皮肤科,浙江嘉善314100 [2]嘉善县中医院中医内科,浙江嘉善314100

出　　处：《新中医》2024年第19期121-125,共5页New Chinese Medicine

摘　　要：目的:观察中西医结合治疗湿热蕴结型中重度寻常型痤疮的疗效。方法:选择102例寻常型痤疮患者,按随机数字表法分为西医组和中西医组各51例。西医组给予红蓝光照射、罗红霉素分散片及夫西地酸乳膏治疗,中西医组在西医组基础上加枇杷清肺饮治疗。共治疗8周。比较2组临床疗效、不良反应及复发率;比较2组治疗前后中医证候积分及肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、睾酮(T)、促卵泡激素(FSH)、促黄体激素(LH)、雌二醇(E_(2))水平。结果:中西医组的总有效率为94.12%,高于西医组80.39%(P<0.05)。治疗后,2组焮热脱屑、丘疹脓包、面部潮红、瘙痒肿痛中医证候积分均降低(P<0.05),且中西医组低于西医组(P<0.05)。治疗后,2组血清TNF-α、IL-6水平均降低(P<0.05),且中西医组低于西医组(P<0.05)。治疗后,2组血清FSH、LH、E_(2)水平均升高(P<0.05),且中西医组高于西医组(P<0.05);2组血清T水平均降低(P<0.05),且中西医组低于西医组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。随访3个月,中西医组复发率4.17%,低于西医组21.95%(P<0.05)。结论:中西医结合治疗湿热蕴结型中重度寻常型痤疮可有效改善临床症状,调节血清炎症因子及性激素水平,降低复发率,且安全性好。Objective:To observe the curative effect of integrated Chinese and western medicine on moderate to severe acne vulgaris of damp-heat accumulation type.Methods:A total of 102 patients with acne vulgaris were selected and divided into western medicine group and the Chinese and western medicine group according to the random number table method,with 51 cases in each group.The western medicine group was treated with irradiation of red and blue light,Roxithromycin Dispersible Tablets and Fusidic Acid Cream,and the Chinese and western medicine group was additionally treated with Pipa Qingfei Decoction based on the treatment of the western medicine group.The two groups were treated for eight weeks.The clinical effects,incidence of adverse reactions and recurrence rates were compared between the two groups;the traditional Chinese medicine(TCM)syndrome scores and the levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),testosterone(T),follicle-stimulating hormone(FSH),luteinizing hormone(LH)and estradiol(E_(2))were compared before and after treatment between the two groups.Results:The total effective rate was 94.12%in the Chinese and western medicine group,higher than that of 80.39%in the western medicine group(P<0.05).After treatment,the TCM syndrome scores of inflammation and desquamation,papule and pustule,congested cheeks,and itching,swelling and pain in the two groups were decreased(P<0.05),and the above scores in the Chinese and western medicine group were lower than those in the western medicine group(P<0.05).After treatment,the levels of serum TNF-αand IL-6 in the two groups were reduced(P<0.05),and the above two levels in the Chinese and western medicine group were lower than those in the western medicine group(P<0.05).After treatment,the levels of serum FSH,LH and E_(2) in the two groups were elevated(P<0.05),and the levels in the Chinese and western medicine group were higher than those in the western medicine group(P<0.05).The levels of serum T in the two groups were down-regulated(P<0.05),and the T

关 键 词：寻常型痤疮 湿热蕴结型 枇杷清肺饮 中医证候积分 炎症因子 性激素 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]