阿奇霉素干混悬剂与阿莫西林克拉维酸钾治疗小儿肺炎的临床效果研究  

Evaluation of drug resistance of azithromycin for suspension and amoxicillin and clavulanate potassium in the treatment of pneumonia in children

作　　者：郑雪金 汪丹 余奇平 ZHENG Xuejin;WANG Dan;YU Qiping(Department of Pharmacy,Shangrao Maternal and Child Health Hospital,Shangrao,Jiangxi,334100,China;Department of Pharmacy,Shangrao Municipal Hospital,Shangrao,Jiangxi,334100,China;Department of Pharmacy,Guixi Health Service Center,Guixi,Jiangxi,335000,China)

机构地区：[1]上饶市妇幼保健院药剂科,江西上饶334100 [2]上饶市立医院药剂科,江西上饶334100 [3]贵溪市卫生健康服务中心药剂科,江西贵溪335000

出　　处：《当代医学》2024年第16期13-17,共5页Contemporary Medicine

基　　金：江西省卫生健康委科技计划项目(202312319)。

摘　　要：目的探讨应用阿奇霉素干混悬剂与阿莫西林克拉维酸钾治疗小儿肺炎的耐药性。方法选取2020年1月至2022年5月上饶市妇幼保健院收治的106例小儿肺炎患者作为研究对象,采用简单随机化方法分为对照组与观察组,每组53例。对照组采用阿莫西林克拉维酸钾治疗,观察组采用阿奇霉素干混悬剂治疗。比较两组治疗前后免疫功能[IgA、IgM、IgG]、肺功能[第1秒用力呼气容积(forced expiratory volume in the first second,FEV1)、用力肺活量(forced vital capacity,FVC)、最大呼气流速(peak expiratory flow rate,PEF)、用力呼气50%速流(50%maximal expiratory flow,MEF50)]、血清细胞因子[白细胞介素-6(interleukin-6,IL-6)、人干扰素γ(human interferonγ,IFN-γ)、单核细胞趋化蛋白-4(monocyte chemoattractant protein-4,MCP-4)]、临床疗效、不良反应发生情况及症状体征改善时间。结果治疗后,两组血清IgA、IgG、IgM水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。治疗后,两组FEV1、FVC、PEF、MEF50均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,两组血清MCP-4、IFN-γ、IL-6水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。观察组咳嗽消失时间、退热时间、肺部啰音消失时间及住院时间均短于对照组,差异有统计学意义(P<0.05)。结论阿奇霉素干混悬剂治疗小儿肺炎疗效显著,可改善患者免疫功能和肺功能,调节细胞因子水平,缩短症状体征改善时间,且安全性较高,值得临床推广应用。Objective To explore the drug resistance of azithromycin dry suspension and amoxicillin clavulanate potassium in the treatment of pediatric pneumonia.Method:106 pediatric pneumonia patients admitted to Shangrao Maternal and Child Health Hospital from January 2020 to May 2022 were selected as the research subjects.They were randomly divided into a control group and an observation group using a simple randomization method,with 53 cases in each group.The control group was treated with amoxicillin and clavulanate potassium,while the observation group was treated with azithromycin dry suspension.The immune function[immunoglobulin A(IgA),immunoglobulin M(IgM),immunoglobulin G(IgG)],lung function[forced expiratory volume in one second(FEV1),forced vital capacity(FVC),maximum expiratory flow rate(PEF),forced expiratory 50%flow rate(MEF50)],serum cytokines[interleukin-6(IL-6),human interferon gamma(IFN-γ),monocyte chemoattractant protein-4(MCP-4)],clinical efficacy,incidence of adverse reactions,and time to improvement of symptoms and signs before and after treatment were compared between two groups.Results After treatment,the levels of serum IgA,IgG,and IgM of the two groups were higher than before treatment,and the observation group was higher than the control group,and the differences were statistically significant(P<0.05).After treatment,FEV1,FVC,PEF,and MEF50 of the two groups were higher than before treatment,and the observation group was higher than the control group,and the differences were statistically significant(P<0.05).The total effective rate in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the average levels of serum MCP-4,IFN-γ,and IL-6 of the two groups were lower than before treatment,and the observation group was lower than the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups.The

关 键 词：阿奇霉素干混悬剂 阿莫西林克拉维酸钾 小儿肺炎 

分 类 号：R725.6[医药卫生—儿科]