复方丹参滴丸配合阿托伐他汀对冠心病患者行经皮冠状动脉介入术后血管内皮功能和血管炎性反应的影响  

Effects of Compound Danshen Dripping Pills Combined with Atorvastatin on Vascular Endothelial Function and Vasculitic Response in Patients with Coronary Heart Disease after PCI

作　　者：许辉[1] 陈峰[1] 王景军 XU Hui;CHEN Feng;WANG Jingjun(Department of Pharmacy,Xiangya Hospital of Central South University,Changsha 410008,Hunan,China;Tashy Pharmaceutical Co.,LTD,Tianjin 300410,China)

机构地区：[1]中南大学湘雅医院药学部,湖南长沙410008 [2]天士力医药集团股份有限公司,天津300410

出　　处：《世界复合医学》2024年第6期72-75,共4页World Journal of Complex Medicine

摘　　要：目的分析复方丹参滴丸配合阿托伐他汀对冠状动脉粥样硬化性心脏病(简称冠心病)患者行经皮冠状动脉介入术(percutaneous coronary intervention,PCI)后血管内皮功能和血管炎性反应的影响。方法选取2023年1月—2024年1月中南大学湘雅医院收治的94例冠心病患者为研究对象,所有患者均接受PCI,按治疗方法不同分组,每组47例。单药组采用阿托伐他汀治疗,联合组给予复方丹参滴丸、阿托伐他汀联合治疗,对比两组临床疗效、血管内皮功能、血管炎性反应。结果联合组临床总有效率为95.74%(45/47),高于单药组的74.47%(35/47),差异有统计学意义(χ^(2)=9.598,P<0.05)。治疗8周后,联合组的血管性血友病因子、内皮素-1、肿瘤坏死因子-α、白细胞介素-6、超敏C反应蛋白水平低于单药组,血清一氧化氮水平高于单药组,差异有统计学意义(P均<0.05)。结论冠心病患者PCI术后应用复方丹参滴丸配合阿托伐他汀治疗,可有效抑制炎症因子释放,改善血管内皮功能,临床疗效显著。Objective To analyze the effects of compound Danshen Dropping Pills combined with atorvastatin on vascular endothelial function and vasculitic response in coronary heart disease after percutaneous coronary intervention(PCI).Methods A total of 94 patients with coronary heart disease admitted to Xiangya Hospital of Central South University from January 2023 to January 2024 were selected as the study objects,all patients underwent PCI,and were divided into 47 patients in each group according to different treatment methods.The monotherapy group was treated with atorvastatin,and the combination group was treated with compound Danshan Dropping Pills combined with atorvastatin.The clinical efficacy,vascular endothelial function and vasculoinflammatory response were compared between the two groups.Results The total effective rate of combination group was 95.74%(45/47),which was higher than 74.47%(35/47)of monotherapy group,and the difference was statistically significant(χ^(2)=9.598,P<0.05).After 8 weeks of treatment,the levels of von Willeophilia factor,endothelin-1,tumor necrosis factor-α,interleukin-6 and hypersensitive C-reactive protein in combination group were lower than those in monotherapy group,and the serum nitric oxide level was higher than that in monotherapy group,and the differences were statistically significant(all P<0.05).Conclusion In patients with coronary heart disease after PCI,the use of compound Danshen Dripping Pills combined with atorvastatin can effectively inhibit the release of inflammatory factors and improve vascular endothelial function,and the clinical effect is significant.

关 键 词：复方丹参滴丸 阿托伐他汀 冠状动脉粥样硬化性心脏病 经皮冠状动脉介入术 血管内皮功能 血管炎性反应 

分 类 号：R541[医药卫生—心血管疾病]