基于金/三维石墨烯水凝胶复合材料修饰的石墨烯电化学晶体管高灵敏检测多巴胺  

Au/Three-dimensional Graphene Hydrogel Modified Graphene Electrochemical Transistor for Highly Sensitive Detection of Dopamine

作　　者：王汝灵 蔡志伟 潘俊字 谭如男 何云斌 常钢 WANG Ru-Ling;CAI Zhi-Wei;PAN Jun-Zi;TAN Ru-Nan;HE Yun-Bin;CHANG Gang(Ministry-of-Education Key Laboratory for the Green Preparation andApplication of Functional Materials,Hubei Key Laboratory of Polymer Materials,School of Materials Science andEngineering,Hubei University,Wuhan 430062,China)

机构地区：[1]湖北大学材料科学与工程学院,高分子材料湖北省重点实验室,功能材料绿色制备与应用教育部重点实验室,武汉430062

出　　处：《分析化学》2024年第9期1307-1315,共9页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金项目(Nos.52272106,62274057);湖北省自然科学基金项目(No.2022EHB023)资助。

摘　　要：本研究采用水热法成功制备了三维石墨烯水凝胶(3D graphene hydrogel,3DGH),将其与金纳米粒子(Gold nanoparticles,AuNPs)复合,构建了Au/3DGH石墨烯电化学晶体管(Graphene electrochemical transistor,GECT)多巴胺(DA)传感器。AuNPs是一种高效的电催化材料,但其在电沉积过程中易团聚。3DGH疏松多孔的网状结构提供了大量的附着位点,有效防止了AuNPs的团聚。通过将Au/3DGH修饰于传感器的栅极上,利用Au/3DGH对DA良好的电催化性能以及GECT的高灵敏度,成功实现了DA的高灵敏检测。Au/3DGH修饰的GECT传感器的检出限低至20 nmol/L,线性范围为20 nmol/L~2.5 mmol/L。此传感器展现出高灵敏度、优异的选择性和较高的稳定性,有望应用于疾病预防与临床监测中DA的高灵敏便携式检测。Three-dimensional graphene hydrogel(3DGH)was successfully prepared through a hydrothermal method,followed by its composition with gold nanoparticles(AuNPs)to construct a highly sensitive Au/3DGH graphene electrochemical transistor(GECT)dopamine(DA)sensor.AuNPs are efficient electrocatalytic materials.However,their tendency to aggregate during electrodeposition hinds the practical application.The porous and interconnected network structure of 3DGH provided abundant attachment sites,effectively preventing AuNPs aggregation.By modifying the sensor′s gate with Au/3DGH,the excellent electrocatalytic performance of Au/3DGH towards DA and the high sensitivity of GECT were utilized to achieve highly sensitive detection of DA.The sensor exhibited a low detection limit of 20 nmol/L and a linear range of 20 nmol/L to 2.5 mmol/L.Remarkably,the sensor showed high sensitivity,excellent selectivity and strong stability,and hold great potnetial in highly sensitive portable detection of DA in disease prevention and clinical monitoring.

关 键 词：多巴胺 三维石墨烯 金纳米粒子 石墨烯晶体管 

分 类 号：O657.1[理学—分析化学] TB33[理学—化学] R313[一般工业技术—材料科学与工程]