肢端肥大症颅颌面畸形的诊治  

Diagnosis and surgical management of craniofacial deformities in acromegaly

作　　者：陈新焰 靳小雷 Chen Xinyan;Jin Xiaolei(Department of Cranio-Maxillofacial Surgery,Plastic Surgery Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100144,China)

机构地区：[1]中国医学科学院北京协和医学院整形外科医院颅颌面外科,北京100144

出　　处：《中华整形外科杂志》2024年第9期1012-1017,共6页Chinese Journal of Plastic Surgery

摘　　要：肢端肥大症是一种由于体内生长激素产生过多而导致的慢性内分泌代谢性疾病。患者常伴有颧骨突出、下颌前突、咬合异常、舌体肥厚等典型颅颌面畸形表现。该病早期筛查、诊断往往比较困难, 患者就诊时多已出现不可逆颅颌面表现。畸形矫治需在激素水平稳定的基础上进行。该文阐述了肢端肥大症的临床诊断、早期筛查与颅颌面畸形矫治。Acromegaly is a chronic disease predominantly caused by the hypersecretion of growth hormone(GH),typically due to a pituitary adenoma.The characteristic craniofacial deformities include pronounced zygomatic arches,frontal bossing,prognathism,dental malocclusion and macroglossia.It’s recommended that facial reconstructive interventions be deferred until the patient’s serum GH levels have been consistently normalized for at least 12 months.This review summarized the current knowledge on diagnosis,screening and facial management strategies for this disease.

关 键 词：肢端肥大症 颅颌面畸形 面容识别 

分 类 号：R584.11[医药卫生—内分泌] R782.2[医药卫生—内科学]