干细胞凋亡小体调控组织再生的机制与应用  

Mechanism and application of stem cell-derived apoptotic bodies in regulating tissue regeneration

作　　者：朱宇帆 陈曦航 廖云君[1] Zhu Yufan;Chen Xihang;Liao Yunjun(Department of Plastic and Cosmetic Surgery,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China)

机构地区：[1]南方医科大学南方医院整形外科,广州510515

出　　处：《中华整形外科杂志》2024年第9期1018-1025,共8页Chinese Journal of Plastic Surgery

基　　金：国家自然科学基金(81971852)。

摘　　要：凋亡小体再生疗法正在成为一种新的且有巨大潜能的无细胞治疗方式, 但是干细胞凋亡小体在组织再生方面的作用机制和应用尚未得到充分关注和研究。该文首先概述了凋亡小体的生理及病理作用、形成与释放过程、富集与纯化方法, 进一步介绍了干细胞凋亡小体调控不同器官组织再生的可能机制, 以及基于凋亡小体的再生疗法和药物递送载体, 并对工程化凋亡小体应用于再生医学的前景进行了展望。Apoptotic bodies(ApoBDs)therapy is a novel and promising cell-free therapeutic strategy.However,the therapeutic mechanism and application of stem cells derived ApoBDs in tissue regeneration have not yet received adequate attention and research evidence.This review summarized the physiological and pathological effects,formation,release,enrichment and purification process of ApoBDs in detail.Furthermore,this review introduced the possible mechanism researches of stem cell-derived ApoBDs regulating regeneration of different organs and tissues,evaluated the possible strategies for their applications as drug delivery carrier,and prospected the development of the engineered modified ApoBDs in regenerative medicine.

关 键 词：干细胞 凋亡小体 组织再生 药物递送载体 

分 类 号：R622[医药卫生—整形外科]