骶神经磁刺激治疗老年女性药物难治性膀胱过度活动症临床观察  

Clinical Observation of Sacral Magnetic Stimulation in the Treatment of Refractory OveractiveBladder in Elderly Women

作　　者：杨波[1] 赵亮 谭丹[1] 霍文谦 YANG Bo;ZHAO Liang;TAN Dan;HUO Wenqian(Chonggang General Hospital,Chongqing,China 400080)

机构地区：[1]重钢总医院,重庆400080

出　　处：《中国药业》2024年第20期101-104,共4页China Pharmaceuticals

基　　金：重庆市卫生健康委医学科研项目[2022WSJK061]。

摘　　要：目的探讨骶神经磁刺激对老年女性药物难治性膀胱过度活动症(OAB)的临床疗效。方法选取医院2020年2月至2022年3月收治的抗胆碱能药物治疗失败的老年女性OAB患者60例,按治疗顺序随机分为观察组和对照组,各30例。观察组患者予骶神经磁刺激,对照组患者完成相同流程(但不予刺激强度)。结果治疗后1周及4周时,观察组患者24 h排尿次数、24 h尿急次数均显著少于对照组,OAB症状评分显著低于对照组,尿失禁生活质量评分显著高于对照组(P<0.05);观察组患者初始尿意膀胱容量、急迫尿意膀胱容量、膀胱顺应性均显著大于对照组(P<0.05),逼尿肌过度活动发生率显著低于对照组(P<0.05);两组其他尿流动力学指标无显著差异(P>0.05)。结论骶神经磁刺激能明显改善OAB症状且无创,有望成为老年女性药物难治性OAB新的治疗选择。Objective To investigate the clinical efficacy of sacral magnetic stimulation(SMS)in the treatment of refractory overactive bladder(OAB)in elderly women.Methods Sixty elderly female patients with OAB refractory to anticholinergic drugs admitted to the hospital from February 2020 to March 2022 were selected and randomly divided into the observation group and the control group based on the orders of treatment,with 30 cases in each group.The patients in the observation group received SMS,while the patients in the control group received the same procedure without stimulation intensity.Results At one week and four weeks after treatment,the 24-hour micturition frequency and 24-hour urgent micturition frequency in the observation group were significantly fewer than those in the control group,the OAB symptom score was significantly lower than that in the control group,the incontinence quality of life questionnaire(I-QOL)score was significantly higher than that in the control group(P<0.05);the volume at first desire(VFD),volume at urgent desire(VUD),and bladder compliance(BC)in the observation group were significantly greater than those in the control group,the incidence of detrusor overactivity(DO)was significantly lower than that in the control group(P<0.05);there was no significant difference in other urinary flow indexes between the two groups(P>0.05).Conclusion SMS can significantly improve the OAB symptoms and is non-invasive,which is expected to be a new treatment option for refractory OAB in elderly women.

关 键 词：老年女性 抗胆碱能药物 骶神经磁刺激 药物难治性膀胱过度活动症 临床疗效 尿流动力学 

分 类 号：R969.3[医药卫生—药理学]