冠心病合并抑郁与NLRP3炎性小体的关系探讨  

Relationship between NLRP3 Inflammasome and Depression in Coronary Heart Disease

作　　者：冀承 梁健 于睿[1] JI Cheng;LIANG Jian;YU Rui(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China)

机构地区：[1]辽宁中医药大学,辽宁沈阳110847

出　　处：《实用中医内科杂志》2024年第10期30-35,共6页Journal of Practical Traditional Chinese Internal Medicine

基　　金：国家自然科学基金资助项目(82274494)。

摘　　要：随着生活方式改变,冠心病与抑郁发病逐年增多,并且冠心病与抑郁共病患者数量也逐年升高,双心模式越发被关注与重视。在中医中冠心病属于胸痹范畴,抑郁属于脏躁、百合病范畴,两者病位均属五脏之“心”。NLRP3是模式识别受体家族演化而来的下游蛋白,其成熟后形成NLRP3炎性小体并释放Caspase-1、IL-1β、IL-18。NLRP3炎性小体及其下游炎性因子参与众多炎性反应,可引起糖尿病、关节炎等多种炎性疾病。在双心疾病中,NLRP3炎性小体在冠心病与抑郁发病过程中均起到重要作用,这与中医“心主神志”“心主血脉”的一心两用相契合。同时在中药治疗双心疾病过程中,对NLRP3炎性小体及其下游炎性因子有明确影响。该文旨在探讨NLRP3炎性小体在双心疾病发病与治疗过程中的影响,为双心疾病临床治疗与双心医学完善与发展提供参考。With the change of lifestyle,the incidence of coronary heart disease and depression is increasing year by year,and the number of patients with coronary heart disease and depression is also increasing year by year.In traditional Chinese medicine,coronary heart disease belongs to the category of chest impediment,depression belongs to the category of Zangzao and Baihe disease,both of which belong to"heart"of the five Zang-organs.NLRP3 is a downstream protein evolved from the pattern recognition receptor family,which forms the NLRP3 inflammasome and releases caspase-1,interleukin-1β(IL-1β)and interleukin-18(IL-18)after maturation.NLRP3 inflammasome and its downstream inflammatory factors participate in many inflammatory reactions and can cause many inflammatory diseases such as diabetes and arthritis.In bicardiac diseases,NLRP3 inflammatorome plays an important role in the pathogenesis of coronary heart disease and depression,which is consistent with the dual use of"heart governing spirit and spirit"and"heart governing blood"in traditional Chinese medicine.At the same time,in the course of the treatment of double heart diseases,traditional Chinese medicine has a clear effect on the NLRP3 inflammatory body and its downstream inflammatory factors.The purpose of this study was to investigate the effect of NLRP3 inflammatorome on the pathogenesis and treatment of bicardiac diseases,and to provide reference for the clinical treatment of bicardiac diseases and the improvement and development of bicardiac medicine.

关 键 词：冠心病 双心 NLRP3 炎性小体 

分 类 号：R259[医药卫生—中西医结合]