石菖蒲治疗血管性认知障碍的机制研究进展  

Effects of Shichangpu(Acori Tatarinowii Rhizoma) on Vascular Cognitive Impairment and Potential Mechanisms

作　　者：刘彩芳 方兴[2] 王娇 杜春云 LIU Caifang;FANG Xing;WANG Jiao;DU Chunyun(Guangxi University of Chinese Medicine,Nanning 530200,Guangxi,China;Ruikang Hospital,Guangxi University of Traditional Chinese Medicine,Nanning 530011,Guangxi,China)

机构地区：[1]广西中医药大学研究生院,广西南宁530200 [2]广西中医药大学附属瑞康医院,广西南宁530011

出　　处：《实用中医内科杂志》2024年第10期88-91,共4页Journal of Practical Traditional Chinese Internal Medicine

基　　金：广西中医药适宜技术开发与推广项目(GZSY21-31)。

摘　　要：血管性认知障碍(vascular cognitive impairment, VCI)是一种严重危害人类健康的疾病,目前临床治疗主要以提高认知功能、改善脑缺血和控制精神行为为主。近些年来中药在治疗VCI的基础及研究方面取得一定的成果,其中石菖蒲是最为突出的,具有开窍豁痰、醒神益智等作用。现代研究证明石菖蒲中含有挥发油成分以及生物碱类、黄酮类、有机酸等非挥发性成分,对中枢神经系统疾病具有治疗作用,可诱导血管性认知障碍细胞凋亡,调节神经元信号等多种活性,从而达到治疗血管性认知障碍的作用。基于以上几点对石菖蒲在治疗血管性认知障碍方面的影响及机制进行综述,为其临床合理应用、科学有效开发提供参考。Vascular cognitive impairment(VCI)is a disease that seriously endangers human health,and the current clinical treatment mainly focuses on improving cognitive function,relieving cerebral ischemia and controlling mental behavior.In recent years,traditional Chinese medicine has made certain achievements in the basic and research aspects of treating VCI,among which Shichangpu(Acori Tatarinowii Rhizoma)is mostly prominent,with the functions of opening the orifices and expelling phlegm,waking up the spirit and benefiting the intellect,and so on.Modern research has proved that Shichangpu(Acori Tatarinowii Rhizoma)contains volatile oil components as well as alkaloids,flavonoids,organic acids and other non-volatile components,which have therapeutic effects on central nervous system disorders,can induce apoptosis of VCI and regulate neuron signaling and other activities,so as to achieve the role of treating vascular cognitive impairment.Based on the above points,the effects and mechanisms of Shichangpu(Acori Tatarinowii Rhizoma)in the treatment of VCI were reviewed to provide reference for its rational clinical application and scientific and effective development.

关 键 词：石菖蒲 血管性认知障碍 机制 综述 

分 类 号：R277.7[医药卫生—中医学]