基于JAK/STAT通路中医药治疗急性缺血性脑卒中的研究进展  

Advances in the Treatment of Acute Cerebral Infarction with Traditional Chinese Medicine Based on JAK/STAT pathway

作　　者：顾浩平 杨洋[1] 严年文[1] GU Haoping;YANG Yang;YAN Nianwen(People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine,350000,China)

机构地区：[1]福建中医药大学附属人民医院,福建福州350000

出　　处：《实用中医内科杂志》2024年第10期121-124,共4页Journal of Practical Traditional Chinese Internal Medicine

基　　金：福建省引导性科技计划项目(2023Y0032)。

摘　　要：脑梗死是我国高发疾病,其发病机制复杂,涉及多个信号通路。JAK/STAT通路在脑梗死发病过程中的作用逐渐受到关注。中医药在脑梗死治疗中展现出独特优势,但其作用于该通路的机制尚未完全明确。文章以JAK/STAT信号通路作为切入点,对该通路进行系统概述,总结在中医药治疗缺血性脑卒中的有效成分和相关靶点,以期为中医药治疗缺血性脑卒中提供了新的思路和方法。Acute cerebral infarction is a highly prevalent disease in China,characterized by complex pathogenesis involving multiple signaling pathways.The role of the JAK/STAT pathway in the pathogenesis of cerebral infarction has garnered increasing attention.Traditional Chinese medicine has demonstrated unique advantages in treating cerebral infarction;however,its mechanism of action on this pathway remains incompletely elucidated.This paper systematically summarizes the JAK/STAT signaling pathway as a starting point and further consolidates effective components and related targets for ischemic stroke treatment using traditional Chinese medicine,aiming to provide novel ideas and approaches for traditional Chinese medicine-based management of ischemic stroke.

关 键 词：缺血性脑卒中 中风 JAK/STAT信号转导通路 中医药 

分 类 号：R277.7[医药卫生—中医学]