To drain or not to drain after distal pancreatectomy: reflexions on the PANDORINA trial  

作　　者：Maxime Constant Alexandre Doussot 

机构地区：[1]Department of Digestive and Surgical Oncology,Liver Transplantation Unit,CHU Besancon,Besançon,France

出　　处：《Hepatobiliary Surgery and Nutrition》2024年第4期675-677,共3页肝胆外科与营养（英文）

摘　　要：We read with great interest the PANDORINA study(1).This international multicenter(mostly from the Netherlands)randomized controlled trial aimed at determining whether omitting drainage after distal pancreatectomy(DP)was equivalent in terms of complications to systematic drainage placement.The primary outcome was the occurrence of severe complications at 90 days defined as Dindo-Clavien grade≥3.The main secondary outcome was the occurrence of grade B–C postoperative pancreatic fistula(POPF)at 90 days.For both outcomes,the non-inferiority threshold was set at 8%.Randomization was performed intraoperatively,stratified by annual center volume(high volume defined as DP≥40/year)and the risk of POPF according to the distal fistula risk score(D-FRS)combining pancreas thickness(high risk,>19 mm)and main pancreatic duct diameter(high risk,>3 mm)measured both at the isthmus(2).

关 键 词：Drainage distal pancreatectomy(DP) randomized controlled trial 

分 类 号：R657.5[医药卫生—外科学]