Does ischemia-free machine perfusion lead to early allograft dysfunction (EAD) free liver transplantation?  

作　　者：Hani M.Wadei Kristopher P.Croome 

机构地区：[1]Division of Kidney and Pancreas Transplant,Department of Transplant,Mayo Clinic,Jacksonville,FL,USA [2]Division of Transplant Surgery,Department of Transplant,Mayo Clinic,Jacksonville,FL,USA

出　　处：《Hepatobiliary Surgery and Nutrition》2024年第4期678-680,共3页肝胆外科与营养（英文）

摘　　要：Normothermic machine perfusion(NMP)is an innovative technique used in solid organ transplantation that involves perfusing the organ with specialized solution or leukocyte depleted red blood cells at near-normal body temperature aiming at mimicking physiological conditions,and providing optimal conditions for organ preservation which leads to reduced risk of ischemia reperfusion injury(IRI)when compared to the standard static cold storage(SCS)(1).One of the key advantages of NMP is its ability to assess the quality of the organ in real-time and assessment of the organ performance prior to transplantation.By continuously monitoring parameters such as blood flow,oxygen consumption,and lactate production,clinicians can evaluate the viability of the organ and make more informed decisions about its suitability for transplantation.This real-time assessment can help reduce the risk of transplanting organs that may not function optimally or have a higher likelihood of complications post-transplant.Additionally,NMP may expand the pool of donor organs by allowing for the use of organs that may have been deemed marginal or unsuitable for transplantation using traditional methods(1,2).

关 键 词：Early allograft dysfunction(EAD) normothermic machine perfusion(NMP) liver transplant outcomes 

分 类 号：R657.3[医药卫生—外科学]