布鲁氏菌主要外膜蛋白研究进展  

Research progress in Brucella main outer membrane proteins

作　　者：辛雪强 佟彤 王玉金 盛宇杰 徐正中 陈祥 XIN Xue-qiang;TONG Tong;WANG Yu-jin;SHENG Yu-jie;XU Zheng-zhong;CHEN Xiang(Jiangsu Key Laboratory of Zoonosis/Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses,Yangzhou University,Yangzhou 225009,China;Key Laboratory of Prevention and Control of Biological Hazard Factors(Animal Origin)for Agrifood Safety and Quality,Ministry of Agriculture and Rural Affairs,Yangzhou University,Yangzhou 225009,China)

机构地区：[1]扬州大学江苏省人兽共患病学重点实验室/江苏省动物重要疫病与人兽共患病防控协同创新中心,扬州225009 [2]扬州大学农业农村部农产品质量安全生物性危害因子(动物源)控制重点实验室,扬州225009

出　　处：《中国人兽共患病学报》2024年第9期872-879,共8页Chinese Journal of Zoonoses

基　　金：国家重点研发计划(No.2021YFD1800403);江苏高等学校大学生创新创业训练计划项目(No.202311117042Z);江苏高校优势学科建设工程项目(PAPD)。

摘　　要：布鲁氏菌病是一种世界范围流行的细菌性人兽共患传染病,由布鲁氏菌属细菌引起,给畜牧业生产和公共卫生安全带来了极大的威胁。外膜蛋白是布鲁氏菌主要的免疫和保护性抗原,与布鲁氏菌的毒力、免疫调节和胞内寄生等特性密切相关。本文对布鲁氏菌主要外膜蛋白的研究进展予以综述,从而促进对布鲁氏菌抗原特性的理解,为布鲁氏菌新型诊断方法的建立和疫苗设计提供参考。Brucellosis,a worldwide epidemic bacterial zoonotic infectious disease caused by bacteria of the genus Brucella,jeopardizes livestock production and poses a major threat to public health safety.Among the various components of Brucella,the outer membrane proteins play crucial roles as the primary immune and protective antigens.These proteins are closely associated with Brucella’s virulence,regulation of the immune response,and ability to survive and multiply within host cells.This article summarizes recent research progress in the primary outer membrane proteins of Brucella,and offers a synthesized view of the current knowledge landscape.Understanding the antigenic characteristics of Brucella outer membrane proteins may substantially contribute to the establishment of new diagnostic methods and the design of new vaccines,thus potentially leading to more effective prevention strategies against brucellosis.The review provides a reference for future studies and may aid in brucellosis control efforts.

关 键 词：布鲁氏菌 外膜蛋白 抗原特性 

分 类 号：R378.5[医药卫生—病原生物学]