药物递送系统介导的脑胶质瘤放疗增敏  

Drug delivery systems for sensitization of glioblastoma radiotherapy

作　　者：刘明萱 郭赟 孙涛 LIU Mingxuan;GUO Yun;SUN Tao(Key Laboratory of Smart Drug Delivery(Fudan University)of Ministry of Education,School of Pharmacy,Fudan University,Shanghai 201203,China)

机构地区：[1]复旦大学药学院智能化递药教育部重点实验室,上海201203

出　　处：《中国药科大学学报》2024年第5期624-633,共10页Journal of China Pharmaceutical University

基　　金：上海市科技创新计划自然科学基金项目(22ZR1414100);平原实验室开放基金项目(2023PY-OP-0106)。

摘　　要：脑胶质瘤是中枢神经系统常见恶性肿瘤,经常出现放疗耐受性。药物递送系统有助于放疗增敏剂的血脑屏障跨越和脑胶质瘤的靶向递送,进而增敏放疗疗效,受到越来越多的关注。本文重点总结了放疗耐受与自身DNA损伤修复机制、具有DNA和膜攻击性的活性氧自由基清除和脑胶质瘤干细胞的快速增殖的相关性,从探讨了无机纳米材料、有机复合材料和仿生递药系统等药物递送系统在解决跨屏障递送难题上的表现,总结了放疗增敏剂的跨血脑屏障和肿瘤靶向递送的递药系统设计方法,并为解决纳米递送系统临床转化问题提供了可能的方向。Glioblastoma is a common malignant tumor in the central nervous system,often exhibiting radiation resistance.Drug delivery systems can help to overcome the blood-brain barrier and targeted delivery of radiation sensitizers to glioblastoma,thereby enhancing the efficacy of radiation therapy,which has received increasing attention.This review focuses on the relationship between radiation resistance and the intrinsic DNA damage repair mechanism,the clearance of reactive oxygen species with DNA and membrane attack,and the rapid proliferation of glioblastoma stem cells.It also discusses the performance of inorganic nanomaterials,organic composite materials,and bionic drug delivery systems in solving the problem of trans-barrier delivery,and summarizes the design method of drug delivery systems for crossing the blood-brain barrier and targeted delivery of radiation sensitizers to glioblastoma,to provide some possible direction for solving the clinical translation problems of nano delivery systems.

关 键 词：脑胶质瘤 药物递送系统 放射耐受性 放疗增敏 肿瘤微环境 

分 类 号：R944[医药卫生—药剂学]