阿胶强骨口服液增强免疫力的作用评价  

Effect of Ejiao Qianggu Oral Liquid on enhancing immunity

作　　者：刘瑞 王晓敏 孟丽燕 瞿思琦 刘利 陈伟 LIU Rui;WANG Xiao-min;MENG Li-yan;QU Si-qi;LIU Li;CHEN Wei(Key Laboratory of Bone Health and TCM Development Key Technology Corps,Urumqi 830011,China;Xinjiang Huashidan Pharmaceutical Research Co.,Ltd.,Urumqi 830011,China)

机构地区：[1]骨健康中医药研究兵团重点实验室,新疆乌鲁木齐830011 [2]新疆华世丹药物研究有限责任公司,新疆乌鲁木齐830011

出　　处：《云南民族大学学报（自然科学版）》2024年第5期570-574,共5页Journal of Yunnan Minzu University:Natural Sciences Edition

基　　金：“十四五”重大专项“阿胶强骨口服液”等特色大品种培育及中药民族药新药创制研究(2022A03017-2);新疆中药民族药物质基础研究创新团队(2023CB002)。

摘　　要：探讨阿胶强骨口服液增强免疫力的作用.以盐酸左旋咪唑、贞芪颗粒作为阳性对照,分别以不同剂量的阿胶强骨口服液给小鼠连续灌胃2周,检测对小鼠体重、胸腺、脾脏器官、脾淋巴细胞转化、碳廓清、巨噬细胞吞噬活性功能、免疫球蛋白IgG、lgM、lgA、cAMP和cGMP含量的影响.结果发现,阿胶强骨口服液可促进小鼠脾淋巴细胞的增殖转化(p<0.05);提高巨噬细胞的吞噬中性红(p<0.01)和金黄色葡萄球菌(p<0.01)的功能;并对正常小鼠IgM有显著促进提升作用(p<0.05).阿胶强骨口服液具有一定的增强免疫力的作用.The effect of Ejiao Qianggu Oral Liquid on enhancing immunity was investigated in this study.Leimidazole hydrochloride and Zhenqi granules were used as positive controls.Ejiao Jianggu oral liquid was given to mice for 2 weeks,and the effects on body weight,thymus,spleen organs,splenic lymphocyte transformation,carbon clearance,macrophage phagocytosis activity,immunoglobulin IgG,lgM,lgA,cAMP and cGMP were detected.Ejiao Qianggu Oral Liquid could promote the proliferation and transformation of spleen lymphocytes in mice(p<0.05).Improve the phagocytic function of macrophages of neutral red(p<0.05)and Staphylococcus aureus(p<0.01);Moreover,it significantly promoted the IgM of normal mice(p<0.05).Ejiao Qianggu Oral Liquid can enhance immunity to some extent.

关 键 词：阿胶强骨口服液 小鼠 免疫力 

分 类 号：R259[医药卫生—中西医结合]