体外受精-胚胎移植术受孕者心理状态情况及影响妊娠结局相关因素  

Psychological status of in vitro fertilisation-embryo transfer recipients and the influencing factors of pregnancy outcome

作　　者：张云 刘嘉 韩亚梅 陈萍 沈春玲 ZHANG Yun;LIU Jia;HAN Yamei;CHEN Ping;SHEN Chunling(Suzhou Hospital Affilitated to Nanjing Medical University(Suzhou City Hospital),Suzhou 215000,China)

机构地区：[1]南京医科大学附属苏州医院(苏州市立医院),江苏省苏州市215000

出　　处：《护理实践与研究》2024年第10期1511-1516,共6页Nursing Practice and Research

基　　金：南京医科大学姑苏学院科研项目(编号:GSKY20220402)。

摘　　要：目的分析体外受精-胚胎移植术受孕者心理状态情况及影响妊娠结局相关因素。方法选取2021年10月—2022年12月医院收治的280例体外受精-胚胎移植术受孕者为研究组,另选取160例于医院接受孕检的正常受孕孕妇为对照组,评估两组心理状态情况,统计体外受精-胚胎移植术受孕者妊娠结局及相关因素。结果与对照组相比,研究组SDS、SAS评分较高,具有统计学差异(P<0.05)。280例体外受精-胚胎移植术受孕者中有162例妊娠成功,118例妊娠失败。单因素分析显示,体外受精-胚胎移植术受孕者妊娠结局与居住地、月收入、不孕类型、可移植胚胎数无关,无统计学差异(P>0.05);体外受精-胚胎移植术受孕者妊娠结局与年龄、文化程度、不孕年限、BMI、优质胚胎数、人绒毛膜促性腺激素(HCG)日子宫膜厚度、基础促卵泡生成素(FSH)、SDS评分、SAS评分有关,与妊娠成功体外受精-胚胎移植术受孕者相比,妊娠失败者≥35岁、文化程度初中及以下、不孕年限≥3年、BMI≥28、优质胚胎数<4枚、HCG日子宫膜厚度<8 mm、基础FSH≥25 U/L、SDS评分≥53分、SAS评分≥50分占比较高,差异具有统计学意义(P<0.05)。以体外受精-胚胎移植术受孕者妊娠结局为因变量(妊娠成功=0;妊娠失败=1),选择单因素分析中P<0.05的变量进行多因素Logistics回归分析,结果显示年龄、文化程度、不孕年限、BMI、优质胚胎数、HCG日子宫膜厚度、基础FSH、SDS评分、SAS评分为影响体外受精-胚胎移植术受孕者妊娠结局的主要因素(P<0.05)。结论体外受精-胚胎移植术受孕者焦虑、抑郁评分较高,体外受精-胚胎移植术受孕者妊娠结局与年龄、文化程度、不孕年限、BMI、优质胚胎数、HCG日子宫膜厚度、基础FSH、SDS评分、SAS评分相关。Objective To analyse the psychological status of in vitro fertilization-embryo transfer recipients and the factors aff ecting pregnancy outcome.Methods A total of 280 cases of IVF-embryo transplant recipients admitted to the hospital from October 2021 to December 2022 were selected as the study group,160 cases of normal pregnant women who underwent pregnancy test in the hospital were selected as the control group,to assess the psychological state of the two groups,and to statistically assess the outcome of pregnancy and related factors in IVF-embryo transplant recipients.Results Compared with the control group,the SDS and SAS scores of the study group were higher,with statistically significant differences(P<0.05).Among the 280 cases of IVFET,162 pregnancies were successful and 118 pregnancies were unsuccessful.Univariate analysis showed that the pregnancy outcome of IVF-embryo transfer recipients was not related with the resident place,monthly income,type of infertility,and the number of embryos that could be transplanted,and there was no statistically significant difference(P>0.05).The pregnancy outcome of IVF-embryo transfer recipients was not related with age,education,infertility,BMI,number of high-quality embryos,thickness of the uterine membrane on the day of human chorionic gonadotropic hormone(HCG),basal folliculogenesis(FSH),basal folliculogenesis(FH),and the number of embryos that were transferred.In comparison with successful IVF-ET recipients,those with pregnancy failure were≥35 years old,education background were junior high school or below,infertile for≥3 years,BMI≥28 kg/m2,number of good quality embryos<4,thickness of uterine membrane<8 mm on the day of HCG,basal FSH≥25 U/L,SDS score≥53 points and SAS score≥50 points were higher,and the difference was statistically significant(P<0.05).Taking the pregnancy outcome of IVF-embryo transfer recipients as the dependent variable(pregnancy success=0;pregnancy failure=1),the multifactorial Logistics regression analysis was conducted by selecting

关 键 词：体外受精-胚胎移植术 心理状态 妊娠结局 前瞻性研究 

分 类 号：R47[医药卫生—护理学]