一种延胡索根提取物分散液的功效研究  

Study on the efficacy of a dispersed extract of Corydalis yanhusuo root extract dispersion

作　　者：陈冬杰 吴雅勤 林厦 陈来成 杨荣鑫 沈国锋 CHEN Dong-jie;WU Ya-qin;LIN Xia;CHEN Lai-cheng;YANG Rong-xin;SHEN Guo-feng(Guangzhou Hemgathion Biotechnology Co.,Ltd.,Guangzhou,Guangdong 510800,China;Guangzhou Hengya Biochemical Co.,Ltd.,Guangzhou,Guangdong 510800,China;Guangzhou Linxia Cosmetics Co.,Ltd.,Guangzhou,Guangdong 510800,China)

机构地区：[1]广州麻尚会生物科技有限公司,广东广州510800 [2]广州恒雅生物化工有限公司,广东广州510800 [3]广州林厦化妆品有限公司,广东广州510800

出　　处：《日用化学品科学》2024年第10期52-55,76,共5页Detergent & Cosmetics

基　　金：延胡索提取物化妆品应用研究开发(2024440111000662)。

摘　　要：以延胡索根提取物分散液(CTR50)为研究对象,通过细胞毒性实验、体内外抗氧化实验、细胞划痕愈合实验研究了延胡索根提取物分散液的相关活性。结果表明,延胡索根提取物分散液对HaCaT细胞无细胞毒性;当延胡索根提取物分散液含量为5%时,对DPPH自由基的清除率为35.05%,对羟自由基清除能力较弱;CTR50可以明显提高HaCaT细胞内SOD活力,增加UVB诱导的HaCaT细胞中抗氧化因子GSH的含量,提高皮肤氧化稳定性;显著促进HaCaT细胞划痕部位愈合能力。由此可见,延胡索根提取物分散液具有作为天然护肤品功效原料的潜力,为其在化妆品领域的开发应用提供理论依据。As a traditional Chinese herbal medicine component,Corydalis yanhusuo is gradually attracting the attention of the skin care industry.In this study,Corydalis yanhusuo root extract dispersion(CTR50)was used as the research object.The related activities of Corydalis yanhusuo root extract dispersion were studied by cytotoxicity test,in vitro and in vivo antioxidant test and cell scratch healing test.The results showed that the dispersion of Corydalis yanhusuo root extract dispersion had no cytotoxicity to HaCaT cells.When the concentration of Corydalis yanhusuo extract dispersion was 5%,the scavenging rate of DPPH free radical was 35.05%,and the scavenging ability of hydroxyl radical was weak;CTR50 can significantly increase the activity of SOD in HaCaT cells,increase the content of antioxidant factor GSH in HaCaT cells induced by UVB,and improve the oxidative stability of skin;it significantly promoted the healing ability of HaCaT cells at the scratch site.It can be seen that thedispersion of Corydalis yanhusuo root extract dispersion has the potential to be used as a functional raw material for natural skin care products,which provides a theoretical basis for its development and application in the field of cosmetics.

关 键 词：延胡索根提取物 安全性 抗氧化 愈合 

分 类 号：TQ658[化学工程—精细化工]