甘油三酯葡萄糖指数与心肌梗死后室间隔穿孔患者30天预后的相关性研究患者的临床特征及预后比  

Triglyceride glucose index for predicting 30-day mortality in patients with acute myocardial infarction with ventricular septal rupture

作　　者：刘永[1] 赵彤 罗晓亮 高晓津 李佳 张峻 程慧[1] 高方明[1] 李国庆[1] LIU Yong;ZHAO Tong;LUO Xiao-liang;GAO Xiao-jin;LI Jia;ZHANG Jun;CHENG Hui;GAO Fang-ming;LI Guo-qing(Department of Cardiology,People’s Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830001,China;Department of cardiology,National Center for Cardiovascular Diseases and Fuwai Hospital,CAMS and PUMC,Beijing 100037,China)

机构地区：[1]新疆维吾尔自治区人民医院心脏与泛血管医学诊疗中心,新疆维吾尔自治区乌鲁木齐市830001 [2]中国医学科学院、北京协和医学院、国家心血管病中心、阜外医院冠心病中心

出　　处：《中国心血管病研究》2024年第8期730-734,共5页Chinese Journal of Cardiovascular Research

摘　　要：目的探讨甘油三酯葡萄糖指数(TyG)与心肌梗死后室间隔穿孔患者30天全因死亡率的关系。方法回顾性分析2009年1月至2023年10月中国医学科学院阜外医院和新疆维吾尔自治区人民医院冠心病重症监护病区收治的急性心肌梗死合并室间隔穿孔患者(n=132)的临床资料及30天预后情况,根据TyG均值分为低TyG组(TyG≤9.25,n=71)和高TyG组(TyG>9.25,n=61)。采用多因素Cox回归分析及Kaplan-Meier分析来验证TyG指数的应用价值。结果与低TyG组(TyG≤9.25)相比,高TyG组患者组年龄更大[(67.6±8.4)岁比(64.0±10.2)岁,P=0.028],男性比例更高(50.8%比31.0%,P=0.020),白细胞水平上升幅度更大[(13.54±5.55)×10^(9)/L比(11.03±4.45)×10^(9)/L,P=0.005],30天全因死亡率更高(57.4%比36.6%,P=0.017)。多因素回归分析提示,低TyG指数(HR=0.502,95%CI 0.302~0.835,P=0.008)是30天全因死亡的保护性预测因素。结论TyG指数是急性心肌梗死合并室间隔穿孔30天全因死亡的潜在预测指标。Objective To investigate the impacts of triglyceride-glucose(TyG)index on 30-day outcomes in patients with acute myocardial infarction(AMI)complicated with ventricular septal rupture(VSR).Methods A total of 132 patients diagnosed of AMI complicated with VSR from January 2009 to October 2023 in Fuwai Hospital and People’s Hospital of Xinjiang Uygur Autonomous Region were collected and dividid into the low TyG group(TyG≤9.25,n=71)and high TyG group(TyG>9.25,n=61).The clinical features,hospital related examination results,treatment and prognosis of these patients were recorded.Multivariable Cox regression analysis and Kaplan-Meier analysis were used to evaluate the prognostic value of TyG index in the patients.Results Compared with the low TyG group,the patients of the high TyG group were older[(67.6±8.4)years vs.(64.0±10.2)years,P=0.028],with a higher proportion of males(50.8%vs.31.0%,P=0.020),a greater increase of white blood cell level[(13.54±5.55)×10^(9)/L vs.(11.03±4.45)×10^(9)/L,P=0.005]and a higher 30 day all-cause mortality rate(57.4%vs.36.6%,P=0.017).Multivariate regression analysis suggested low TyG index was the independent protective predictor of 30-day all-cause mortality(HR=0.502,95%CI 0.302-0.835,P=0.008).Conclusion TyG index may be associated with 30-day mortality in patients with acute myocardial infarction with ventricular septal rupture.

关 键 词：甘油三酯葡萄糖指数 心肌梗死 室间隔穿孔 病死率 

分 类 号：R542.22[医药卫生—心血管疾病]