水热-辐射联用技术制备普鲁士蓝/MPC/蚕丝布复合材料及其ROS清除性能研究  

Preparation of Prussian Blue/MPC/Silk Cloth Composite Material by Hydrothermal-Radiation Combination Technology and Its ROS Removal Performance

作　　者：唐冬旭 刘坤 付娌丽 周士忠 张洋林 李月生[2,3] TANG Dongxu;LIU Kun;FU Lili;ZHOU Shizhong;ZHANG Yanglin;LI Yuesheng(School of Pharmacy,Xianning Medical College,Hubei University of Science and Technology,Xianning 437100,China;Hubei Key Labortory of Radiation Chemistry and Functional Materials,Hubei University of Science and Technology,Xianning 437100,China;School of Nuclear Technology and Chemical Biology,Hubei University of Science and Technology,Xianning 437100,China)

机构地区：[1]湖北科技学院医学部药学院,湖北咸宁437100 [2]湖北科技学院辐射化学与功能材料湖北省重点实验室,湖北咸宁437100 [3]湖北科技学院核技术与化学生物学院,湖北咸宁437100

出　　处：《化学与生物工程》2024年第10期58-63,共6页Chemistry & Bioengineering

基　　金：国家自然科学基金项目(11405050);湖北省高等学校优秀中青年科技创新团队项目(T2020022)。

摘　　要：以蚕丝布作为基底原料,通过水热法使普鲁士蓝纳米颗粒(PBNPs)在蚕丝布的表面生长,再通过辐射接枝法将2-甲基丙烯酰氧乙基磷酰胆碱(MPC)接枝在蚕丝布上,制备了普鲁士蓝/MPC/蚕丝布复合材料(PMS),通过XRD、FTIR、TG、DTG、XPS等手段对PMS进行了表征,并探究了PMS的活性氧自由基(ROS)清除能力。结果表明,PBNPs成功在蚕丝布上原位生长,MPC成功接枝在蚕丝布上;PMS的结构稳定,具有良好的ROS清除能力,可以有效保护细胞免受ROS攻击。PMS有望成为一种性能优异、有前景的糖尿病伤口护理敷料。Taking silk cloth as a base material,we prepared Prussian Blue/MPC/silk cloth composite material(PMS)through two steps as follows:Prussian Blue nanoparticles(PBNPs)were grown on the surface of silk cloth by a hydrothermal method,and then 2-methylacryloxyethylphosphocholine(MPC)was grafted onto silk cloth by a radiation grafting method.Moreover,we characterized the structure of PMS by XRD,FTIR,TG,DTG,and XPS,and investigated the scavenging ability of PMS against reactive oxygen species(ROS).The results indicate that PBNPs are successfully grown in situ on the surface of silk cloth and MPC is successfully grafted on silk cloth.The structure of PMS is stable and PMS has good ROS scavenging ability,which can effectively protect cells from ROS attacks.PMS is expected to be an excellent and promising nursing dressing for diabetic wound.

关 键 词：普鲁士蓝 辐射接枝 ROS清除 糖尿病伤口 

分 类 号：TQ31[化学工程—高聚物工业]