The molecular and cellular choreography of early mammalian lung development  

作　　者：Xianfa Yang Yingying Chen Yun Yang Shiting Li Panpan Mi Naihe Jing 

机构地区：[1]Guangzhou National Laboratory,No.9 XingDaoHuanBei Road,Guangzhou International Bio Island,Guangzhou 510005,Guangdong Province,China [2]Guangzhou National Laboratory,Guangzhou,Guangdong Province,China [3]Guangzhou Medical University,Guangzhou,Guangdong Province,China [4]Institute of Biomedical Research,Yunnan University,Kunming,Yunnan Province,China [5]Department of Histology and Embryology,Zhongshan School of Medicine,Sun Yat-sen University,Guangzhou,Guangdong Province,China

出　　处：《Medical Review》2024年第3期192-206,共15页医学评论（英文）

基　　金：supported in part by the National Key Basic Research and Development Program of China(2019YFA0801402,2018YFA0107200,2018YFA0801402,2018YFA0800100);the Major Project of Guangzhou National Laboratory(GZNL2023A02005);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16020501,XDA16020404);the National Natural Science Foundation of China(32130030,31900454).

摘　　要：Mammalian lung development starts from a specific cluster of endodermal cells situated within the ventral foregut region.With the orchestrating of delicate choreography of transcription factors,signaling pathways,and cell–cell communications,the endodermal diverticulum extends into the surrounding mesenchyme,and builds the cellular and structural basis of the complex respiratory system.This review provides a comprehensive overview of the current molecular insights of mammalian lung development,with a particular focus on the early stage of lung cell fate differentiation and spatial patterning.Furthermore,we explore the implications of several congenital respiratory diseases and the relevance to early organogenesis.Finally,we summarize the unprecedented knowledge concerning lung cell compositions,regulatory networks as well as the promising prospect for gaining an unbiased understanding of lung development and lung malformations through stateof-the-art single-cell omics.

关 键 词：ORGANOGENESIS embryonic pattern formation cell-to-cell interaction lung malformation single-cell analysis 

分 类 号：R392[医药卫生—免疫学]