DNA-based nanostructures for RNA delivery  

作　　者：Yuanyuan Wu Liangzhi Luo Ziyang Hao Dongsheng Liu 

机构地区：[1]Beijing SupraCirc Biotechnology Co.,Ltd,Beijing,China [2]School of Pharmaceutical Sciences,Capital Medical University,Beijing,China [3]School of Pharmaceutical Sciences,Capital Medical University,Beijing 100069,China [4]Department of Chemistry,Engineering Research Center of Advanced Rare Earth Materials,(Ministry of Education),Tsinghua University,Beijing 100084,China

出　　处：《Medical Review》2024年第3期207-224,共18页医学评论（英文）

基　　金：National Basic Research Plan of China(2023YFA0915201);Beijing Municipal Science&Technology Commission(Z231100007223003);National Natural Science Foundation of China(21890731,21821001,21890730,and 32270627)。

摘　　要：RNA-based therapeutics have emerged as a promising approach for the treatment of various diseases,including cancer,genetic disorders,and infectious diseases.However,the delivery of RNA molecules into target cells has been a major challenge due to their susceptibility to degradation and inefficient cellular uptake.To overcome these hurdles,DNA-based nano technology offers an unprecedented opportunity as a potential delivery platform for RNA therapeutics.Due to its excellent characteristics such as programmability and biocompatibility,these DNA-based nanostructures,composed of DNA molecules assembled into precise and programmable structures,have garnered significant attention as ideal building materials for protecting and delivering RNA payloads to the desired cellular destinations.In this review,we highlight the current progress in the design and application of three DNA-based nanostructures:DNA origami,lipid-nanoparticle(LNP)technology related to frame guided assembly(FGA),and DNA hydrogel for the delivery of RNA molecules.Their biomedical applications are briefly discussed and the challenges and future perspectives in this field are also highlighted.

关 键 词：DNA origami frame guided assembly(FGA) DNA hydrogel RNA delivery gene therapy DNA-based nanostructures 

分 类 号：TB383[一般工业技术—材料科学与工程]